| Literature DB >> 18625554 |
Zachary K Sweeney1, Sahaja Acharya, Andrew Briggs, James P Dunn, Todd R Elworthy, Jennifer Fretland, Anthony M Giannetti, Gabrielle Heilek, Yu Li, Ann C Kaiser, Michael Martin, Y David Saito, Mark Smith, Judy M Suh, Steven Swallow, Jeffrey Wu, Julie Q Hang, Amy S Zhou, Klaus Klumpp.
Abstract
Novel non-nucleoside inhibitors of HIV-RT that contain pyridazinone isosteres were prepared, and a series of triazolinones were found to be potent inhibitors of HIV replication. These compounds were active against several NNRTI-resistant virus strains. Pharmacokinetic studies indicated that inhibitor 7e has good bioavailability in rats. Several fragments of inhibitor 7c were prepared, and the binding of these compounds to HIV-RT was analyzed by surface plasmon resonance spectroscopy.Entities:
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Year: 2008 PMID： 18625554 DOI： 10.1016/j.bmcl.2008.06.080
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823