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Literature DB >> 18625434

Hepatitis C and innate immunity: recent advances.

Abstract

Eradication of hepatitis C virus (HCV) infection requires a complex and coordinated interplay between innate and adaptive immune responses that, when it fails, leads to chronic infection. In this review, the innate immune mechanisms by which HCV is sensed and by which HCV undermines host defense are discussed. The critical role of dendritic cells in antigen presentation and T-cell activation in addition to type I interferon production and interference of HCV with innate immune cell functions are reviewed. Finally, current and emerging therapeutic approaches targeting innate immune pathways are evaluated.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2008 PMID： 18625434 PMCID： PMC2593077 DOI： 10.1016/j.cld.2008.03.003

Source DB: PubMed Journal: Clin Liver Dis ISSN： 1089-3261 Impact factor: 6.126

115 in total

1. Major histocompatibility complex class-I presentation impaired in transgenic mice expressing hepatitis C virus structural proteins during dendritic cell maturation.

Authors: Yoichi Hiasa; Hidemi Takahashi; Masumi Shimizu; Hideko Nuriya; Kyoko Tsukiyama-Kohara; Takeshi Tanaka; Norio Horiike; Morikazu Onji; Michinori Kohara
Journal: J Med Virol Date: 2004-10 Impact factor: 2.327

2. Infection and dysfunction of circulating blood dendritic cells and their subsets in chronic hepatitis C virus infection.

Authors: Eiji Tsubouchi; Sk Md Fazle Akbar; Norio Horiike; Morikazu Onji
Journal: J Gastroenterol Date: 2004-08 Impact factor: 7.527

3. Impact of alpha interferon and ribavirin on the function of maturing dendritic cells.

Authors: Eleanor Barnes; Mariolina Salio; Vincenzo Cerundolo; Joanne Medlin; Shona Murphy; Geoffrey Dusheiko; Paul Klenerman
Journal: Antimicrob Agents Chemother Date: 2004-09 Impact factor: 5.191

4. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.

Authors: Sandra S Diebold; Tsuneyasu Kaisho; Hiroaki Hemmi; Shizuo Akira; Caetano Reis e Sousa
Journal: Science Date: 2004-02-19 Impact factor: 47.728

5. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.

Authors: Florian Heil; Hiroaki Hemmi; Hubertus Hochrein; Franziska Ampenberger; Carsten Kirschning; Shizuo Akira; Grayson Lipford; Hermann Wagner; Stefan Bauer
Journal: Science Date: 2004-02-19 Impact factor: 47.728

6. Hepatitis C virus persistence after spontaneous or treatment-induced resolution of hepatitis C.

Authors: Tram N Q Pham; Sonya A MacParland; Patricia M Mulrooney; Helen Cooksley; Nikolai V Naoumov; Tomasz I Michalak
Journal: J Virol Date: 2004-06 Impact factor: 5.103

7. Autocrine/paracrine IL-15 that is required for type I IFN-mediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection.

Authors: Masahisa Jinushi; Tetsuo Takehara; Tomohide Tatsumi; Tatsuya Kanto; Veronika Groh; Thomas Spies; Takahiro Suzuki; Takuya Miyagi; Norio Hayashi
Journal: J Immunol Date: 2003-11-15 Impact factor: 5.422

8. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.

Authors: Etienne Meylan; Kim Burns; Kay Hofmann; Vincent Blancheteau; Fabio Martinon; Michelle Kelliher; Jürg Tschopp
Journal: Nat Immunol Date: 2004-04-04 Impact factor: 25.606

9. Presence of functional dendritic cells in patients chronically infected with hepatitis C virus.

Authors: Randy S Longman; Andrew H Talal; Ira M Jacobson; Matthew L Albert; Charles M Rice
Journal: Blood Date: 2003-10-02 Impact factor: 22.113

10. Lack of phenotypic and functional impairment in dendritic cells from chimpanzees chronically infected with hepatitis C virus.

Authors: Marie Larsson; Ethan Babcock; Arash Grakoui; Naglaa Shoukry; Georg Lauer; Charles Rice; Christopher Walker; Nina Bhardwaj
Journal: J Virol Date: 2004-06 Impact factor: 5.103

25 in total

Review 1. Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patients.

Authors: Gyongyi Szabo; Samir Zakhari
Journal: World J Gastroenterol Date: 2011-05-28 Impact factor: 5.742

Review 2. Adaptive immunity to the hepatitis C virus.

Authors: Christopher M Walker
Journal: Adv Virus Res Date: 2010 Impact factor: 9.937

3. Ex vivo analysis of resident hepatic pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in hepatitis C.

Authors: K Yanagisawa; S Yue; H J van der Vliet; R Wang; N Alatrakchi; L Golden-Mason; D Schuppan; M J Koziel; H R Rosen; M A Exley
Journal: J Viral Hepat Date: 2013-03-11 Impact factor: 3.728

4. Circulating and Exosome-Packaged Hepatitis C Single-Stranded RNA Induce Monocyte Differentiation via TLR7/8 to Polarized Macrophages and Fibrocytes.

Authors: Banishree Saha; Karen Kodys; Adeyinka Adejumo; Gyongyi Szabo
Journal: J Immunol Date: 2017-01-25 Impact factor: 5.422

9. Differential regulation of interleukin-12 (IL-12)/IL-23 by Tim-3 drives T(H)17 cell development during hepatitis C virus infection.

Authors: Jia M Wang; Lei Shi; Cheng J Ma; Xiao J Ji; Ruo S Ying; Xiao Y Wu; Ke S Wang; Guangyu Li; Jonathan P Moorman; Zhi Q Yao
Journal: J Virol Date: 2013-02-06 Impact factor: 5.103

Review 10. Innate immune cell networking in hepatitis C virus infection.

Authors: Banishree Saha; Gyongyi Szabo
Journal: J Leukoc Biol Date: 2014-07-07 Impact factor: 4.962