Literature DB >> 1862526

Serum kinetics of crotoxin from Crotalus durissus terrificus venom in mice: evidence for a rapid clearance.

M Barral-Netto1, R L von Sohsten.   

Abstract

We report on an ELISA for the detection of crotoxin with a detection limit of 1-3 pg/ml of sample. Cross-reactivity with other animal venoms occurred only at concentrations above 1 microgram/ml. Serum kinetics of crotoxin were investigated in BALB/c mice after a single 10 micrograms s.c. dose of venom obtained from Crotalus durissus terrificus. Crotoxin levels were 254 +/- 141 ng/ml serum (X +/- S.E.) 15 min after venom injection, 3.9 +/- 0.5 ng/ml serum at 30 min and undetectable thereafter. The rapid clearance of crotoxin from the serum suggests that the test may be unsuitable for the clinical management of envenomation victims.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1862526     DOI： 10.1016/0041-0101(91)90028-p

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  5 in total

Review 1.  Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation.

Authors:  José María Gutiérrez; Guillermo León; Bruno Lomonte
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447

2.  Pharmacokinetics of Naja sumatrana (equatorial spitting cobra) venom and its major toxins in experimentally envenomed rabbits.

Authors:  Michelle Khai Khun Yap; Nget Hong Tan; Si Mui Sim; Shin Yee Fung; Choo Hock Tan
Journal:  PLoS Negl Trop Dis       Date:  2014-06-05

3.  Bites by the Monocled Cobra, Naja kaouthia, in Chittagong Division, Bangladesh: Epidemiology, Clinical Features of Envenoming and Management of 70 Identified Cases.

Authors:  M A Faiz; M F Ahsan; A Ghose; M R Rahman; R Amin; M Hossain; M N U Tareq; M A Jalil; U Kuch; R D G Theakston; D A Warrell; J B Harris
Journal:  Am J Trop Med Hyg       Date:  2017-01-30       Impact factor: 2.345

4.  Neotropical Rattlesnake (Crotalus simus) Venom Pharmacokinetics in Lymph and Blood Using an Ovine Model.

Authors:  Edgar Neri-Castro; Melisa Bénard-Valle; Dayanira Paniagua; Leslie V Boyer; Lourival D Possani; Fernando López-Casillas; Alejandro Olvera; Camilo Romero; Fernando Zamudio; Alejandro Alagón
Journal:  Toxins (Basel)       Date:  2020-07-17       Impact factor: 4.546

5.  Non-compartmental toxicokinetic studies of the Nigerian Naja nigricollis venom.

Authors:  Auwal A Bala; Sani Malami; Yusuf Abubakar Muhammad; Binta Kurfi; Ismaila Raji; Sanusi Muhammad Salisu; Mustapha Mohammed; George Oche Ambrose; Murtala Jibril; Jacob A Galan; Elda E Sanchez; Basheer A Z Chedi
Journal:  Toxicon X       Date:  2022-04-01
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.