Literature DB >> 18625115

Genes and type 2 diabetes mellitus.

Leif Groop1, Valeriya Lyssenko.   

Abstract

In 2007, five whole genome-wide association studies were published on the genetics of type 2 diabetes mellitus (T2DM), followed by the discovery of 11 genes consistently associated with T2DM. This breakthrough provided the first glimpses of a complete picture of the disease's genetic complexity. Currently, we are only beginning to understand how DNA methylation, histone acetylation, and deacetylation may introduce epigenetic changes throughout one's lifetime. Such changes may influence age-related modifications in gene-expression that contribute to age-related diseases. In the future, the possibility of whole-genome DNA methylation studies may elucidate the extent of these epigenetic effects. This article reviews genes that have recently been determined to be associated with T2DM.

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Year:  2008        PMID： 18625115     DOI： 10.1007/s11892-008-0033-y

Source DB:  PubMed          Journal:  Curr Diab Rep        ISSN： 1534-4827            Impact factor:   4.810


  44 in total

Review 1.  Candidate genes for type 2 diabetes.

Authors:  Hemang Parikh; Leif Groop
Journal:  Rev Endocr Metab Disord       Date:  2004-05       Impact factor: 6.514

2.  Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes.

Authors:  Valeriya Lyssenko; Peter Almgren; Dragi Anevski; Roland Perfekt; Kaj Lahti; Michael Nissén; Bo Isomaa; Björn Forsen; Nils Homström; Carola Saloranta; Marja-Riitta Taskinen; Leif Groop; Tiinamaija Tuomi
Journal:  Diabetes       Date:  2005-01       Impact factor: 9.461

3.  A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.

Authors:  C L Hanis; E Boerwinkle; R Chakraborty; D L Ellsworth; P Concannon; B Stirling; V A Morrison; B Wapelhorst; R S Spielman; K J Gogolin-Ewens; J M Shepard; S R Williams; N Risch; D Hinds; N Iwasaki; M Ogata; Y Omori; C Petzold; H Rietzch; H E Schröder; J Schulze; N J Cox; S Menzel; V V Boriraj; X Chen; L R Lim; T Lindner; L E Mereu; Y Q Wang; K Xiang; K Yamagata; Y Yang; G I Bell
Journal:  Nat Genet       Date:  1996-06       Impact factor: 38.330

4.  Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.

Authors:  Anna L Gloyn; Ewan R Pearson; Jennifer F Antcliff; Peter Proks; G Jan Bruining; Annabelle S Slingerland; Neville Howard; Shubha Srinivasan; José M C L Silva; Janne Molnes; Emma L Edghill; Timothy M Frayling; I Karen Temple; Deborah Mackay; Julian P H Shield; Zdenek Sumnik; Adrian van Rhijn; Jerry K H Wales; Penelope Clark; Shaun Gorman; Javier Aisenberg; Sian Ellard; Pål R Njølstad; Frances M Ashcroft; Andrew T Hattersley
Journal:  N Engl J Med       Date:  2004-04-29       Impact factor: 91.245

5.  Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study.

Authors:  David E Laaksonen; Hanna-Maaria Lakka; Leo K Niskanen; George A Kaplan; Jukka T Salonen; Timo A Lakka
Journal:  Am J Epidemiol       Date:  2002-12-01       Impact factor: 4.897

6.  Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

Authors:  Richa Saxena; Benjamin F Voight; Valeriya Lyssenko; Noël P Burtt; Paul I W de Bakker; Hong Chen; Jeffrey J Roix; Sekar Kathiresan; Joel N Hirschhorn; Mark J Daly; Thomas E Hughes; Leif Groop; David Altshuler; Peter Almgren; Jose C Florez; Joanne Meyer; Kristin Ardlie; Kristina Bengtsson Boström; Bo Isomaa; Guillaume Lettre; Ulf Lindblad; Helen N Lyon; Olle Melander; Christopher Newton-Cheh; Peter Nilsson; Marju Orho-Melander; Lennart Råstam; Elizabeth K Speliotes; Marja-Riitta Taskinen; Tiinamaija Tuomi; Candace Guiducci; Anna Berglund; Joyce Carlson; Lauren Gianniny; Rachel Hackett; Liselotte Hall; Johan Holmkvist; Esa Laurila; Marketa Sjögren; Maria Sterner; Aarti Surti; Margareta Svensson; Malin Svensson; Ryan Tewhey; Brendan Blumenstiel; Melissa Parkin; Matthew Defelice; Rachel Barry; Wendy Brodeur; Jody Camarata; Nancy Chia; Mary Fava; John Gibbons; Bob Handsaker; Claire Healy; Kieu Nguyen; Casey Gates; Carrie Sougnez; Diane Gage; Marcia Nizzari; Stacey B Gabriel; Gung-Wei Chirn; Qicheng Ma; Hemang Parikh; Delwood Richardson; Darrell Ricke; Shaun Purcell
Journal:  Science       Date:  2007-04-26       Impact factor: 47.728

7.  Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

Authors:  Sekar Kathiresan; Olle Melander; Candace Guiducci; Aarti Surti; Noël P Burtt; Mark J Rieder; Gregory M Cooper; Charlotta Roos; Benjamin F Voight; Aki S Havulinna; Björn Wahlstrand; Thomas Hedner; Dolores Corella; E Shyong Tai; Jose M Ordovas; Göran Berglund; Erkki Vartiainen; Pekka Jousilahti; Bo Hedblad; Marja-Riitta Taskinen; Christopher Newton-Cheh; Veikko Salomaa; Leena Peltonen; Leif Groop; David M Altshuler; Marju Orho-Melander
Journal:  Nat Genet       Date:  2008-01-13       Impact factor: 38.330

8.  Diabetes among the three affiliated tribes: correlation with degree of Indian inheritance.

Authors:  J D Brosseau; R C Eelkema; A C Crawford; T A Abe
Journal:  Am J Public Health       Date:  1979-12       Impact factor: 9.308

9.  Mutations in the glucokinase gene of the fetus result in reduced birth weight.

Authors:  A T Hattersley; F Beards; E Ballantyne; M Appleton; R Harvey; S Ellard
Journal:  Nat Genet       Date:  1998-07       Impact factor: 38.330

10.  Variation in FTO contributes to childhood obesity and severe adult obesity.

Authors:  Christian Dina; David Meyre; Sophie Gallina; Emmanuelle Durand; Antje Körner; Peter Jacobson; Lena M S Carlsson; Wieland Kiess; Vincent Vatin; Cecile Lecoeur; Jérome Delplanque; Emmanuel Vaillant; François Pattou; Juan Ruiz; Jacques Weill; Claire Levy-Marchal; Fritz Horber; Natascha Potoczna; Serge Hercberg; Catherine Le Stunff; Pierre Bougnères; Peter Kovacs; Michel Marre; Beverley Balkau; Stéphane Cauchi; Jean-Claude Chèvre; Philippe Froguel
Journal:  Nat Genet       Date:  2007-05-13       Impact factor: 38.330
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  13 in total

1.  Insulin resistance versus beta-cell dysfunction in the pathogenesis of type 2 diabetes.

Authors:  Ele Ferrannini
Journal:  Curr Diab Rep       Date:  2009-06       Impact factor: 4.810

2.  Mexican-American admixture mapping analyses for diabetic nephropathy in type 2 diabetes mellitus.

Authors:  Sharon Adler; Madeleine Pahl; Hanna Abboud; Susanne Nicholas; Eli Ipp; Michael Seldin
Journal:  Semin Nephrol       Date:  2010-03       Impact factor: 5.299

3.  Clinically-Defined Maturity Onset Diabetes of the Young in Omanis: Absence of the common Caucasian gene mutations.

Authors:  Nicholas Jy Woodhouse; Omayma T Elshafie; Ali S Al-Mamari; Nagi Hs Mohammed; Fatma Al-Riyami; Sandy Raeburn
Journal:  Sultan Qaboos Univ Med J       Date:  2010-04-17

4.  Glutaredoxin-1 mediates NADPH-dependent stimulation of calcium-dependent insulin secretion.

Authors:  Thomas M Reinbothe; Rosita Ivarsson; Dai-Qing Li; Omid Niazi; Xingjun Jing; Enming Zhang; Lena Stenson; Ulrika Bryborn; Erik Renström
Journal:  Mol Endocrinol       Date:  2009-03-19

Review 5.  The Effects of Breakfast Consumption and Composition on Metabolic Wellness with a Focus on Carbohydrate Metabolism.

Authors:  Kevin C Maki; Alyssa K Phillips-Eakley; Kristen N Smith
Journal:  Adv Nutr       Date:  2016-05-16       Impact factor: 8.701

Review 6.  "H" for Heterogeneity in the Algorithm for Type 2 Diabetes Management.

Authors:  Pieralice Silvia; Zampetti Simona; Maddaloni Ernesto; Buzzetti Raffaella
Journal:  Curr Diab Rep       Date:  2020-03-20       Impact factor: 4.810

7.  Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets.

Authors:  C Dai; M Brissova; Y Hang; C Thompson; G Poffenberger; A Shostak; Z Chen; R Stein; A C Powers
Journal:  Diabetologia       Date:  2011-12-14       Impact factor: 10.122

8.  Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.

Authors:  Rong Chen; Erik Corona; Martin Sikora; Joel T Dudley; Alex A Morgan; Andres Moreno-Estrada; Geoffrey B Nilsen; David Ruau; Stephen E Lincoln; Carlos D Bustamante; Atul J Butte
Journal:  PLoS Genet       Date:  2012-04-12       Impact factor: 5.917

9.  Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.

Authors:  Ralph A Defronzo
Journal:  Diabetes       Date:  2009-04       Impact factor: 9.461

Review 10.  Goals of treatment for type 2 diabetes: beta-cell preservation for glycemic control.

Authors:  Piero Marchetti; Roberto Lupi; Silvia Del Guerra; Marco Bugliani; Valentina D'Aleo; Margherita Occhipinti; Ugo Boggi; Lorella Marselli; Matilde Masini
Journal:  Diabetes Care       Date:  2009-11       Impact factor: 19.112
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