BACKGROUND: Eosinophilic oesophagitis (EoO) may be a common finding in adults presenting with dysphagia. AIM: To identify the risk factors and prevalence of EoO in an adult population with dysphagia. METHODS: All patients with dysphagia referred for an upper endoscopy (EGD) were asked to participate. Patients completed a detailed questionnaire followed by EGD with four quadrant biopsies in the distal and mid-oesophagus. Primary endpoint was the prevalence of EoO; secondary endpoints included age, gender, asthma, food allergies, gastro-oesophageal reflux disease/dysphagia score and endoscopic findings. RESULTS: Two hundred and sixty-one patients enrolled between December 2005 and January 2007. Thirty-one patients (12%) met pathological criteria for EoO. There was no difference in EoO prevalence within each gender. Mean age of EoO patients was 42 +/- 15 vs. 61 +/- 15 for non-EoO patients (P < 0.001). EoO was diagnosed in 35% of patients <50 years of age. EoO was present in 22% of asthmatics vs. 9% non-asthmatics (P < 0.01). EoO was present in 36.8% of patients with self-reported food allergies vs. 9.3% those without allergy (P < 0.001). A 13/31(42%) of EoO patients did not have the classic EGD findings (rings +/- furrows) and would have been missed without oesophageal biopsies. CONCLUSIONS: Eosinophilic oesophagitis was diagnosed in 12% of the patients presenting with dysphagia with relative risk of 9.5 if age <50 years. Oesophageal biopsies are warranted in patients presenting with dysphagia especially in the younger population. Patients may not present with classic endoscopic findings and EoO can be missed without biopsies.
BACKGROUND:Eosinophilic oesophagitis (EoO) may be a common finding in adults presenting with dysphagia. AIM: To identify the risk factors and prevalence of EoO in an adult population with dysphagia. METHODS: All patients with dysphagia referred for an upper endoscopy (EGD) were asked to participate. Patients completed a detailed questionnaire followed by EGD with four quadrant biopsies in the distal and mid-oesophagus. Primary endpoint was the prevalence of EoO; secondary endpoints included age, gender, asthma, food allergies, gastro-oesophageal reflux disease/dysphagia score and endoscopic findings. RESULTS: Two hundred and sixty-one patients enrolled between December 2005 and January 2007. Thirty-one patients (12%) met pathological criteria for EoO. There was no difference in EoO prevalence within each gender. Mean age of EoO patients was 42 +/- 15 vs. 61 +/- 15 for non-EoO patients (P < 0.001). EoO was diagnosed in 35% of patients <50 years of age. EoO was present in 22% of asthmatics vs. 9% non-asthmatics (P < 0.01). EoO was present in 36.8% of patients with self-reported food allergies vs. 9.3% those without allergy (P < 0.001). A 13/31(42%) of EoO patients did not have the classic EGD findings (rings +/- furrows) and would have been missed without oesophageal biopsies. CONCLUSIONS:Eosinophilic oesophagitis was diagnosed in 12% of the patients presenting with dysphagia with relative risk of 9.5 if age <50 years. Oesophageal biopsies are warranted in patients presenting with dysphagia especially in the younger population. Patients may not present with classic endoscopic findings and EoO can be missed without biopsies.
Authors: Kathryn A Peterson; William J Cobell; Frederic C Clayton; Chaya Krishnamurthy; Jian Ying; Leonard F Pease; Hedieh Saffari; Ann Georgelas; John Fang; Gerald J Gleich; Kristin M Leiferman Journal: Dig Dis Sci Date: 2015-04-23 Impact factor: 3.199
Authors: Evan S Dellon; Rune Erichsen; Lars Pedersen; Nicholas J Shaheen; John A Baron; Henrik T Sørensen; Mogens Vyberg Journal: World J Gastroenterol Date: 2013-01-28 Impact factor: 5.742
Authors: Francesca Fianchi; Giuseppe De Matteis; Rossella Cianci; Marco Pizzoferrato; Silvia Cardone; Maria Anna Nicolazzi; Mariella Fuorlo; Maria Teresa Congedo; Vincenzo Arena; Maria Elena Riccioni; Brunella Barbaro; Giovanni Gambassi Journal: Clin J Gastroenterol Date: 2019-05-03