Literature DB >> 18622757

Polymorphism of prion protein gene in Arctic fox (Vulpes lagopus).

Jiayu Wan1, Xue Bai, Wensen Liu, Jing Xu, Ming Xu, Hongwei Gao.   

Abstract

Prion diseases are fatal neurodegenerative disorders of humans and certain other mammals. Prion protein gene (Prnp) is associated with susceptibility and species barrier to prion diseases. No natural and experimental prion diseases have been documented to date in Arctic fox. In the present study, coding region of Prnp from 135 Arctic foxes were cloned and screened for polymorphisms. Our results indicated that the Arctic fox Prnp open reading frame (ORF) contains 771 nucleotides encoding 257 amino acids. Four single nucleotide polymorphisms (SNPs) (G312C, A337G, C541T, and A723G) were identified. SNPs G312C and A723G produced silent mutations, but SNPs A337G and C541T resulted in a M-V change at codon 113 and R-C at codon 181, respectively. The Arctic fox Prnp amino acid sequence was similar to that of the dog (XM 542906). In short, this study provides preliminary information about genotypes of Prnp in Arctic fox.

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Year:  2008        PMID： 18622757     DOI： 10.1007/s11033-008-9312-6

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  26 in total

1.  Frequencies of PrP gene haplotypes in British sheep flocks and the implications for breeding programmes.

Authors:  W Goldmann; M Baylis; C Chihota; E Stevenson; N Hunter
Journal:  J Appl Microbiol       Date:  2005       Impact factor: 3.772

2.  Two-rung model of a left-handed beta-helix for prions explains species barrier and strain variation in transmissible spongiform encephalopathies.

Authors:  J P M Langedijk; G Fuentes; R Boshuizen; A M J J Bonvin
Journal:  J Mol Biol       Date:  2006-06-05       Impact factor: 5.469

3.  Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques.

Authors:  M Scott; D Foster; C Mirenda; D Serban; F Coufal; M Wälchli; M Torchia; D Groth; G Carlson; S J DeArmond; D Westaway; S B Prusiner
Journal:  Cell       Date:  1989-12-01       Impact factor: 41.582

4.  Subclinical scrapie infection in a resistant species: persistence, replication, and adaptation of infectivity during four passages.

Authors:  Richard Race; Kimberly Meade-White; Anne Raines; Gregory J Raymond; Byron Caughey; Bruce Chesebro
Journal:  J Infect Dis       Date:  2002-12-01       Impact factor: 5.226

5.  Experimental infection of cattle with the agents of transmissible mink encephalopathy and scrapie.

Authors:  M M Robinson; W J Hadlow; D P Knowles; T P Huff; P A Lacy; R F Marsh; J R Gorham
Journal:  J Comp Pathol       Date:  1995-10       Impact factor: 1.311

6.  A new variant of Creutzfeldt-Jakob disease in the UK.

Authors:  R G Will; J W Ironside; M Zeidler; S N Cousens; K Estibeiro; A Alperovitch; S Poser; M Pocchiari; A Hofman; P G Smith
Journal:  Lancet       Date:  1996-04-06       Impact factor: 79.321

7.  Prion protein gene variation among primates.

Authors:  H M Schätzl; M Da Costa; L Taylor; F E Cohen; S B Prusiner
Journal:  J Mol Biol       Date:  1995-01-27       Impact factor: 5.469

8.  The elk PRNP codon 132 polymorphism controls cervid and scrapie prion propagation.

Authors:  Kristi M Green; Shawn R Browning; Tanya S Seward; Jean E Jewell; Dana L Ross; Michael A Green; Elizabeth S Williams; Edward A Hoover; Glenn C Telling
Journal:  J Gen Virol       Date:  2008-02       Impact factor: 3.891

Review 9.  Prions.

Authors:  S B Prusiner
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205

10.  Experimental infection of mink with bovine spongiform encephalopathy.

Authors:  M M Robinson; W J Hadlow; T P Huff; G A Wells; M Dawson; R F Marsh; J R Gorham
Journal:  J Gen Virol       Date:  1994-09       Impact factor: 3.891
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  1 in total

1.  Genetic predictions of prion disease susceptibility in carnivore species based on variability of the prion gene coding region.

Authors:  Paula Stewart; Lauren Campbell; Susan Skogtvedt; Karen A Griffin; Jon M Arnemo; Morten Tryland; Simon Girling; Michael W Miller; Michael A Tranulis; Wilfred Goldmann
Journal:  PLoS One       Date:  2012-12-07       Impact factor: 3.240
  1 in total

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