OBJECTIVE: Circulating estrogen levels have been related to the risk of several female cancers. Blood levels of estrogen are controlled by estrogen synthesis enzymes. Genetic variation of estrogen genes thus may influence circulating estrogen levels. We investigated the associations of genetic polymorphisms in CYP19A1, a critical gene involved in estrogen synthesis, with plasma levels of sex hormones among postmenopausal Chinese women. METHODS: Included in this study were 345 postmenopausal community controls from a population-based case-control study conducted in Shanghai. Fasting blood samples from those women were measured for blood estradiol, estrone, estrone sulfate, and testosterone. A total of 19 genetic polymorphisms in CYP19A1 were genotyped using ABI7900 or PCR-restriction fragment length polymorphism methods. Differences in plasma levels of hormones by genotype were examined using variance analysis. RESULT: The geometric means of plasma levels of estradiol, estrone, estrone sulfate, and testosterone were 10.1, 16.8, 969.0, and 202.9 pg/ml, respectively, for this study population. We found that plasma levels of estrone were associated with rs28566535 (P=0.0180), rs730154 (P=0.0141), and rs936306 (P=0.0274) in block 2. In the same block, the haplotype CGCTA was related to level of estrone (P=0.0064). Single nucleotide polymorphism rs1902584 in block 1 was associated with estradiol only in overweight postmenopausal women. No clear association with sex hormones was noted for the other genetic polymorphisms evaluated in the study. CONCLUSION: Single nucleotide polymorphisms in blocks 1 and 2 of the CYP19A1 gene are related to plasma levels of estrogen among postmenopausal Chinese women and may therefore play an important role in the etiology of hormone-related cancers.
OBJECTIVE: Circulating estrogen levels have been related to the risk of several female cancers. Blood levels of estrogen are controlled by estrogen synthesis enzymes. Genetic variation of estrogen genes thus may influence circulating estrogen levels. We investigated the associations of genetic polymorphisms in CYP19A1, a critical gene involved in estrogen synthesis, with plasma levels of sex hormones among postmenopausal Chinese women. METHODS: Included in this study were 345 postmenopausal community controls from a population-based case-control study conducted in Shanghai. Fasting blood samples from those women were measured for blood estradiol, estrone, estrone sulfate, and testosterone. A total of 19 genetic polymorphisms in CYP19A1 were genotyped using ABI7900 or PCR-restriction fragment length polymorphism methods. Differences in plasma levels of hormones by genotype were examined using variance analysis. RESULT: The geometric means of plasma levels of estradiol, estrone, estrone sulfate, and testosterone were 10.1, 16.8, 969.0, and 202.9 pg/ml, respectively, for this study population. We found that plasma levels of estrone were associated with rs28566535 (P=0.0180), rs730154 (P=0.0141), and rs936306 (P=0.0274) in block 2. In the same block, the haplotype CGCTA was related to level of estrone (P=0.0064). Single nucleotide polymorphism rs1902584 in block 1 was associated with estradiol only in overweight postmenopausal women. No clear association with sex hormones was noted for the other genetic polymorphisms evaluated in the study. CONCLUSION: Single nucleotide polymorphisms in blocks 1 and 2 of the CYP19A1 gene are related to plasma levels of estrogen among postmenopausal Chinese women and may therefore play an important role in the etiology of hormone-related cancers.
Authors: C R Mendelson; G D Means; M S Mahendroo; C J Corbin; M P Steinkampf; S Graham-Lorence; E R Simpson Journal: Biol Reprod Date: 1990-01 Impact factor: 4.285
Authors: V Mohamed-Ali; S Goodrick; A Rawesh; D R Katz; J M Miles; J S Yudkin; S Klein; S W Coppack Journal: J Clin Endocrinol Metab Date: 1997-12 Impact factor: 5.958
Authors: Alison M Dunning; Mitch Dowsett; Catherine S Healey; Louise Tee; Robert N Luben; Elizabeth Folkerd; Karen L Novik; Livia Kelemen; Saeko Ogata; Paul D P Pharoah; Douglas F Easton; N E Day; Bruce A J Ponder Journal: J Natl Cancer Inst Date: 2004-06-16 Impact factor: 13.506
Authors: Christopher A Haiman; Daniel O Stram; Malcolm C Pike; Laurence N Kolonel; Noel P Burtt; David Altshuler; Joel Hirschhorn; Brian E Henderson Journal: Hum Mol Genet Date: 2003-08-27 Impact factor: 6.150
Authors: L Beckmann; A Hüsing; V W Setiawan; P Amiano; F Clavel-Chapelon; S J Chanock; D G Cox; R Diver; L Dossus; H S Feigelson; C Haiman; G Hallmans; R B Hayes; B E Henderson; R N Hoover; D J Hunter; K Khaw; L N Kolonel; P Kraft; E Lund; L Le Marchand; P H M Peeters; E Riboli; D Stram; G Thomas; M J Thun; R Tumino; D Trichopoulos; U Vogel; W C Willett; M Yeager; R Ziegler; S E Hankinson; R Kaaks Journal: J Clin Endocrinol Metab Date: 2010-12-22 Impact factor: 5.958
Authors: Maryfran R Sowers; John F Randolph; Huiyong Zheng; Mary Jannausch; Daniel McConnell; Sharon R Kardia; Carolyn J Crandall; Bin Nan Journal: Clin Endocrinol (Oxf) Date: 2011-05 Impact factor: 3.478
Authors: Jennifer H Lin; JoAnn E Manson; Peter Kraft; Barbara B Cochrane; Marc J Gunter; Rowan T Chlebowski; Shumin M Zhang Journal: BMC Med Genet Date: 2011-05-31 Impact factor: 2.103
Authors: Vidar G Flote; Anne-Sofie Furberg; Anne McTiernan; Hanne Frydenberg; Giske Ursin; Anita Iversen; Trygve Lofteroed; Peter T Ellison; Erik A Wist; Thore Egeland; Tom Wilsgaard; Karen W Makar; Jenny Chang-Claude; Inger Thune Journal: Breast Cancer Res Date: 2014-12-19 Impact factor: 6.466
Authors: Lisa Y Cho; Jae Jeong Yang; Kwang-Pil Ko; Seung Hyun Ma; Aesun Shin; Bo Youl Choi; Dong Soo Han; Kyu Sang Song; Yong Sung Kim; Soung-Hoon Chang; Hai-Rim Shin; Daehee Kang; Keun-Young Yoo; Sue K Park Journal: PLoS One Date: 2012-10-23 Impact factor: 3.240
Authors: Jennifer H Lin; Marc J Gunter; JoAnn E Manson; Kathryn M Rexrode; Nancy R Cook; Peter Kraft; Barbara B Cochrane; Rowan T Chlebowski; Gloria Y F Ho; Shumin M Zhang Journal: PLoS One Date: 2012-07-25 Impact factor: 3.240