OBJECTIVE: To verify whether peptide YY (PYY) and its Y2 receptor (Y2R) gene variants can be associated with obesity or hypertension or both in a cohort of obese children and adolescents. PATIENTS AND METHODS: Two hundred and twenty-nine obese children (105 girls, mean z-score BMI 5.1 +/- 2.4; mean age 10.5 +/- 2.9 years) and 250 age and sex-matched lean controls (130 women, mean z-score BMI 0.5 +/- 1.1; mean age 10.3 +/- 2.8) were enrolled in the study. Height, weight, BMI, waist circumference and 24-h systolic and diastolic blood pressure were measured. Night-time, day-time and 24-h systolic and diastolic blood pressures were evaluated by 24 h ambulatory blood pressure measurement, and appropriate standard deviation scores according to sex, age and height were calculated. Molecular screening of the PYY and Y2R genes was performed. RESULTS: No new mutations were found. We observed three previously described polymorphisms: G767C on PYY and T585C and T936C on Y2R. An association study was carried out in obese patients. No associations were found between the PYY genotypes and the studied phenotypes. The Y2R gene variants, T585C and T936C, which are in almost complete linkage disequilibrium, were found to be associated with night-time, day-time and 24-h systolic and diastolic blood pressures. In particular, subject homozygotes for the T allele showed lower systolic and diastolic blood pressure values compared with the other genotypes. Moreover, obese children homozygous for the T585 allele showed a lower risk of developing hypertension than patients carrying the CC and CT genotypes (chi 6.9; df = 1, P = 0.03; odds ratio = 0.5, 95% confidence interval: 0.27-0.88). CONCLUSION: Our results suggest that Y2R gene variants are involved in blood pressure regulation in obese children and adolescents.
OBJECTIVE: To verify whether peptide YY (PYY) and its Y2 receptor (Y2R) gene variants can be associated with obesity or hypertension or both in a cohort of obesechildren and adolescents. PATIENTS AND METHODS: Two hundred and twenty-nine obesechildren (105 girls, mean z-score BMI 5.1 +/- 2.4; mean age 10.5 +/- 2.9 years) and 250 age and sex-matched lean controls (130 women, mean z-score BMI 0.5 +/- 1.1; mean age 10.3 +/- 2.8) were enrolled in the study. Height, weight, BMI, waist circumference and 24-h systolic and diastolic blood pressure were measured. Night-time, day-time and 24-h systolic and diastolic blood pressures were evaluated by 24 h ambulatory blood pressure measurement, and appropriate standard deviation scores according to sex, age and height were calculated. Molecular screening of the PYY and Y2R genes was performed. RESULTS: No new mutations were found. We observed three previously described polymorphisms: G767C on PYY and T585C and T936C on Y2R. An association study was carried out in obesepatients. No associations were found between the PYY genotypes and the studied phenotypes. The Y2R gene variants, T585C and T936C, which are in almost complete linkage disequilibrium, were found to be associated with night-time, day-time and 24-h systolic and diastolic blood pressures. In particular, subject homozygotes for the T allele showed lower systolic and diastolic blood pressure values compared with the other genotypes. Moreover, obesechildren homozygous for the T585 allele showed a lower risk of developing hypertension than patients carrying the CC and CT genotypes (chi 6.9; df = 1, P = 0.03; odds ratio = 0.5, 95% confidence interval: 0.27-0.88). CONCLUSION: Our results suggest that Y2R gene variants are involved in blood pressure regulation in obesechildren and adolescents.
Authors: Steven C Hunt; Sandra J Hasstedt; Yuanpei Xin; Brian K Dalley; Brett A Milash; Emanuel Yakobson; Richard E Gress; Lance E Davidson; Ted D Adams Journal: Obesity (Silver Spring) Date: 2011-08-04 Impact factor: 5.002
Authors: Pei-An Betty Shih; Lei Wang; Stephane Chiron; Gen Wen; Caroline Nievergelt; Manjula Mahata; Srikrishna Khandrika; Fangwen Rao; Maple M Fung; Sushil K Mahata; Bruce A Hamilton; Daniel T O'Connor Journal: J Clin Endocrinol Metab Date: 2009-10-09 Impact factor: 5.958
Authors: Domenico Cozzolino; Anna Grandone; Antonio Cittadini; Giuseppe Palmiero; Giovanni Esposito; Annamaria De Bellis; Raffaello Furlan; Silverio Perrotta; Laura Perrone; Daniele Torella; Emanuele Miraglia Del Giudice Journal: PLoS One Date: 2015-04-23 Impact factor: 3.240