AIMS: To compare whether novel inflammatory and haemostatic biomarkers are more predictive of well-characterized incident acute coronary syndrome (ACS) than stable angina (SA). METHODS AND RESULTS: We used data from the PRIME Study, a prospective cohort of 9758 asymptomatic middle-aged men recruited in Northern Ireland and France between 1991 and 1993. A nested case-control study was established with the baseline plasma sample of 269 incident cases and 538 matched controls. Odds ratios (ORs) for SA and ACS were estimated by conditional logistic regression analysis. After 5 years of follow-up, 107 incident SA and 162 ACS cases were validated. After adjustment for traditional risk factors, higher circulating levels of hs-CRP, ICAM1, interleukin 6 and interleukin 18 were equally predictive of SA and ACS (all P-values of OR comparison >0.05). In contrast, elevated levels of fibrinogen, von Willebrand factor, and possibly higher level of D-dimers and lower level of tissue factor pathway inhibitor were associated with ACS only. The comparison of the ORs showed a statistically significant difference for von Willebrand factor only [OR(4th vs. 1st quartile) = 2.99 (1.49-6.02) for ACS vs. 0.80 (0.33-1.94) for SA; P(z test) = 0.02]. CONCLUSION: This is the first population-based study suggesting that higher levels of circulating haemostatic markers and of von Willebrand factor, in particular, are significantly more predictive of incident ACS than SA.
AIMS: To compare whether novel inflammatory and haemostatic biomarkers are more predictive of well-characterized incident acute coronary syndrome (ACS) than stable angina (SA). METHODS AND RESULTS: We used data from the PRIME Study, a prospective cohort of 9758 asymptomatic middle-aged men recruited in Northern Ireland and France between 1991 and 1993. A nested case-control study was established with the baseline plasma sample of 269 incident cases and 538 matched controls. Odds ratios (ORs) for SA and ACS were estimated by conditional logistic regression analysis. After 5 years of follow-up, 107 incident SA and 162 ACS cases were validated. After adjustment for traditional risk factors, higher circulating levels of hs-CRP, ICAM1, interleukin 6 and interleukin 18 were equally predictive of SA and ACS (all P-values of OR comparison >0.05). In contrast, elevated levels of fibrinogen, von Willebrand factor, and possibly higher level of D-dimers and lower level of tissue factor pathway inhibitor were associated with ACS only. The comparison of the ORs showed a statistically significant difference for von Willebrand factor only [OR(4th vs. 1st quartile) = 2.99 (1.49-6.02) for ACS vs. 0.80 (0.33-1.94) for SA; P(z test) = 0.02]. CONCLUSION: This is the first population-based study suggesting that higher levels of circulating haemostatic markers and of von Willebrand factor, in particular, are significantly more predictive of incident ACS than SA.
Authors: James H Stein; Eunice Yeh; Joanne M Weber; Claudia Korcarz; Paul M Ridker; Ahmed Tawakol; Priscilla Y Hsue; Judith S Currier; Heather Ribaudo; Carol K C Mitchell Journal: Arterioscler Thromb Vasc Biol Date: 2018-12 Impact factor: 8.311
Authors: Hao Chen; Donghang Zheng; Jennifer Davids; Mee Yong Bartee; Erbin Dai; Liying Liu; Lyubomir Petrov; Colin Macaulay; Robert Thoburn; Eric Sobel; Richard Moyer; Grant McFadden; Alexandra Lucas Journal: Methods Enzymol Date: 2011 Impact factor: 1.600
Authors: F Canouï-Poitrine; G Luc; Z Mallat; E Machez; A Bingham; J Ferrieres; J-B Ruidavets; M Montaye; J Yarnell; B Haas; D Arveiler; P Morange; F Kee; A Evans; P Amouyel; P Ducimetiere; J-P Empana Journal: Neurology Date: 2011-08-17 Impact factor: 9.910
Authors: Danny J Eapen; Pankaj Manocha; Riyaz S Patel; Muhammad Hammadah; Emir Veledar; Christina Wassel; Ravi A Nanjundappa; Sergey Sikora; Dylan Malayter; Peter W F Wilson; Laurence Sperling; Arshed A Quyyumi; Stephen E Epstein Journal: J Am Coll Cardiol Date: 2013-05-09 Impact factor: 24.094
Authors: Imo E Hoefer; Jan-Willem Sels; J Wouter Jukema; Sandrin Bergheanu; Erik Biessen; Elizabeth McClellan; Mat Daemen; Pieter Doevendans; Philip de Groot; Marieke Hillaert; Sebastiaan Horsman; Mustafa Ilhan; Johan Kuiper; Nico Pijls; Ken Redekop; Peter van der Spek; Andrew Stubbs; Eric van de Veer; Johannes Waltenberger; Anton-Jan van Zonneveld; Gerard Pasterkamp Journal: Clin Res Cardiol Date: 2013-08-23 Impact factor: 5.460
Authors: Nima Ghasemzedah; Salim S Hayek; Yi-An Ko; Danny J Eapen; Riyaz S Patel; Pankaj Manocha; Hatem Al Kassem; Mohamed Khayata; Emir Veledar; Dimitrios Kremastinos; Christian W Thorball; Tomasz Pielak; Sergey Sikora; A Maziar Zafari; Stamatios Lerakis; Laurence Sperling; Viola Vaccarino; Stephen E Epstein; Arshed A Quyyumi Journal: Circ Cardiovasc Qual Outcomes Date: 2017-03
Authors: Peter Willeit; Alexander Thompson; Thor Aspelund; Ann Rumley; Gudny Eiriksdottir; Gordon Lowe; Vilmundur Gudnason; Emanuele Di Angelantonio Journal: PLoS One Date: 2013-02-07 Impact factor: 3.240