| Literature DB >> 18621525 |
T D Venu1, S A Khanum, Aiysha Firdouse, B K Manuprasad, Sheena Shashikanth, Riyaz Mohamed, Bannikuppe Sannanaik Vishwanth.
Abstract
Reaction of 6a-f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a-f in excellent yield. The newly synthesized heterocycles were characterized by IR, (1)H NMR, and mass spectral data. Compounds 7a-f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.Entities:
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Year: 2008 PMID： 18621525 DOI： 10.1016/j.bmcl.2008.06.061
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823