| Literature DB >> 18621524 |
Andrew K Takle1, Mark J Bamford, Susannah Davies, Robert P Davis, David K Dean, Alessandra Gaiba, Elaine A Irving, Frank D King, Antoinette Naylor, Christopher A Parr, Alison M Ray, Alastair D Reith, Beverley B Smith, Penelope C Staton, Jon G A Steadman, Tania O Stean, David M Wilson.
Abstract
Modification of the potent imidazole-based B-Raf inhibitor SB-590885 resulted in the identification of a series of furan-based derivatives with enhanced CNS penetration. One such compound, SB-699393 (17), was examined in vivo to challenge the hypothesis that selective B-Raf inhibitors may be of value in the treatment of stroke.Entities:
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Year: 2008 PMID： 18621524 DOI： 10.1016/j.bmcl.2008.06.070
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823