Literature DB >> 18620724

Delivery of immunotherapy with peptide-pulsed blood in macaques.

Robert De Rose1, Caroline S Fernandez, Liyen Loh, Viv Peut, Rosemarie D Mason, Sheilajen Alcantara, Jeanette Reece, Stephen J Kent.   

Abstract

Simple and effective delivery methods for cellular immunotherapies are needed. We assessed ex vivo pulsing of overlapping SIV Gag 15mer peptides onto either whole blood or PBMC in 15 randomly assigned SIV-infected macaques. Both delivery methods were safe and immunogenic, stimulating high levels of broad and polyfunctional Gag-specific CD4 and CD8 T cells. Delivery of overlapping Gag peptides via either whole blood or PBMC is suitable for clinical evaluation.

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Year:  2008        PMID： 18620724     DOI： 10.1016/j.virol.2008.06.006

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  7 in total

1.  Peripheral NKT cells in simian immunodeficiency virus-infected macaques.

Authors:  Caroline S Fernandez; Angela C Chan; Konstantinos Kyparissoudis; Robert De Rose; Dale I Godfrey; Stephen J Kent
Journal:  J Virol       Date:  2008-12-03       Impact factor: 5.103

2.  Timing of immune escape linked to success or failure of vaccination.

Authors:  Jeanette C Reece; Liyen Loh; Sheilajen Alcantara; Caroline S Fernandez; John Stambas; Amy Sexton; Robert De Rose; Janka Petravic; Miles P Davenport; Stephen J Kent
Journal:  PLoS One       Date:  2010-09-16       Impact factor: 3.240

3.  Inactivated simian immunodeficiency virus-pulsed autologous fresh blood cells as an immunotherapy strategy.

Authors:  Rosemarie D Mason; Sheilajen Alcantara; Viv Peut; Liyen Loh; Jeffrey D Lifson; Robert De Rose; Stephen J Kent
Journal:  J Virol       Date:  2008-11-19       Impact factor: 5.103

4.  Circumventing antivector immunity by using adenovirus-infected blood cells for repeated application of adenovirus-vectored vaccines: proof of concept in rhesus macaques.

Authors:  Caijun Sun; Liqiang Feng; Yinfeng Zhang; Lijun Xiao; Weiqi Pan; Chufang Li; Linqi Zhang; Ling Chen
Journal:  J Virol       Date:  2012-08-01       Impact factor: 5.103

5.  Non-immunogenicity of overlapping gag peptides pulsed on autologous cells after vaccination of HIV infected individuals.

Authors:  Henrik N Kløverpris; Akil Jackson; Amanda Handley; Peter Hayes; Jill Gilmour; Lynn Riddell; Fabian Chen; Mark Atkins; Marta Boffito; Bruce D Walker; Jim Ackland; Mark Sullivan; Philip Goulder
Journal:  PLoS One       Date:  2013-10-04       Impact factor: 3.240

6.  Preexisting Virus-Specific T Lymphocytes-Mediated Enhancement of Adenovirus Infections to Human Blood CD14+ Cells.

Authors:  Fengling Feng; Jin Zhao; Pingchao Li; Ruiting Li; Ling Chen; Caijun Sun
Journal:  Viruses       Date:  2019-02-13       Impact factor: 5.048

7.  A randomised, placebo-controlled, first-in-human study of a novel clade C therapeutic peptide vaccine administered ex vivo to autologous white blood cells in HIV infected individuals.

Authors:  Akil Jackson; Henrik N Kløverpris; Marta Boffito; Amanda Handley; Mark Atkins; Peter Hayes; Jill Gilmour; Lynn Riddel; Fabian Chen; Melanie Bailey-Tippets; Bruce Walker; Jim Ackland; Mark Sullivan; Philip Goulder
Journal:  PLoS One       Date:  2013-09-17       Impact factor: 3.240
  7 in total

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