Literature DB >> 18619839

Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1).

Ashok V Purandare1, Zhong Chen, Tram Huynh, Suhong Pang, Jieping Geng, Wayne Vaccaro, Michael A Poss, Jonathan Oconnell, Kimberly Nowak, Lata Jayaraman.   

Abstract

This study reports the identification and Hits to Leads optimization of inhibitors of coactivator associated arginine methyltransferase (CARM1). Compound 7b is a potent, selective inhibitor of CARM1.

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Year:  2008        PMID： 18619839     DOI： 10.1016/j.bmcl.2008.06.026

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  25 in total

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2.  Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.

Authors:  Kevin Bonham; Saskia Hemmers; Yeon-Hee Lim; Dawn M Hill; M G Finn; Kerri A Mowen
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Review 3.  Small Molecule Inhibitors of Protein Arginine Methyltransferases.

Authors:  Hao Hu; Kun Qian; Meng-Chiao Ho; Y George Zheng
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4.  Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1).

Authors:  H Ü Kaniskan; M S Eram; J Liu; D Smil; M L Martini; Y Shen; V Santhakumar; P J Brown; C Arrowsmith; M Vedadi; J Jin
Journal:  Medchemcomm       Date:  2016-07-13       Impact factor: 3.597

Review 5.  Protein methyltransferases as a target class for drug discovery.

Authors:  Robert A Copeland; Michael E Solomon; Victoria M Richon
Journal:  Nat Rev Drug Discov       Date:  2009-09       Impact factor: 84.694

Review 6.  Chemical biology of protein arginine modifications in epigenetic regulation.

Authors:  Jakob Fuhrmann; Kathleen W Clancy; Paul R Thompson
Journal:  Chem Rev       Date:  2015-05-13       Impact factor: 60.622

Review 7.  Inhibitors of Protein Methyltransferases and Demethylases.

Authors:  H Ümit Kaniskan; Michael L Martini; Jian Jin
Journal:  Chem Rev       Date:  2017-03-24       Impact factor: 60.622

8.  Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.

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Journal:  J Med Chem       Date:  2012-11-02       Impact factor: 7.446

9.  A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.

Authors:  Elayne Chan-Penebre; Kristy G Kuplast; Christina R Majer; P Ann Boriack-Sjodin; Tim J Wigle; L Danielle Johnston; Nathalie Rioux; Michael J Munchhof; Lei Jin; Suzanne L Jacques; Kip A West; Trupti Lingaraj; Kimberly Stickland; Scott A Ribich; Alejandra Raimondi; Margaret Porter Scott; Nigel J Waters; Roy M Pollock; Jesse J Smith; Olena Barbash; Melissa Pappalardi; Thau F Ho; Kelvin Nurse; Khyati P Oza; Kathleen T Gallagher; Ryan Kruger; Mikel P Moyer; Robert A Copeland; Richard Chesworth; Kenneth W Duncan
Journal:  Nat Chem Biol       Date:  2015-04-27       Impact factor: 15.040

10.  Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.

Authors:  Feng Liu; Fengling Li; Anqi Ma; Elena Dobrovetsky; Aiping Dong; Cen Gao; Ilia Korboukh; Jing Liu; David Smil; Peter J Brown; Stephen V Frye; Cheryl H Arrowsmith; Matthieu Schapira; Masoud Vedadi; Jian Jin
Journal:  J Med Chem       Date:  2013-02-27       Impact factor: 7.446
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