BACKGROUND: This prospective study compared extracorporeal shockwave treatment (ESWT) with hyperbaric oxygen therapy (HBO) in chronic diabetic foot ulcers. PATIENTS AND METHODS: Seventy-two patients with 72 chronic diabetic foot ulcers were randomly divided into two groups of similar demographics with 34 patients with 36 ulcers in the ESWT group and 36 patients with 36 ulcers in the HBO group. Patients in the ESWT group received 300 + 100/cm(2) impulses of shockwave at 0.11 mJ/cm(2) energy flux density every 2 wk for 6 wk, whereas patients in the HBO group received HBO daily for 20 treatments. The evaluations included clinical assessment of the ulcers with photo-documentation, blood flow perfusion scan, bacteriological examination, histological study, and immunohistochemical analysis. RESULTS: The overall results showed completely healed in 31%, improved in 58%, and unchanged in 11% for the ESWT group and 22% completely healed, 50% improved, and 28% unchanged for the HBO group. The ESWT group showed significantly better clinical results and local blood flow perfusion, higher cell concentration, and activity than the HBO group. On immunohistochemical analysis, the ESWT group demonstrated significant increases in endothelial nitric oxide synthase, vessel endothelial growth factor, and proliferation cell nuclear antigen expressions and a decrease in transference-mediated digoxigenin-deoxy-UTP nick end-labeling expression than the HBO group. CONCLUSIONS:ESWT appears to be more effective than HBO in chronic diabetic foot ulcers.
RCT Entities:
BACKGROUND: This prospective study compared extracorporeal shockwave treatment (ESWT) with hyperbaric oxygen therapy (HBO) in chronic diabetic foot ulcers. PATIENTS AND METHODS: Seventy-two patients with 72 chronic diabetic foot ulcers were randomly divided into two groups of similar demographics with 34 patients with 36 ulcers in the ESWT group and 36 patients with 36 ulcers in the HBO group. Patients in the ESWT group received 300 + 100/cm(2) impulses of shockwave at 0.11 mJ/cm(2) energy flux density every 2 wk for 6 wk, whereas patients in the HBO group received HBO daily for 20 treatments. The evaluations included clinical assessment of the ulcers with photo-documentation, blood flow perfusion scan, bacteriological examination, histological study, and immunohistochemical analysis. RESULTS: The overall results showed completely healed in 31%, improved in 58%, and unchanged in 11% for the ESWT group and 22% completely healed, 50% improved, and 28% unchanged for the HBO group. The ESWT group showed significantly better clinical results and local blood flow perfusion, higher cell concentration, and activity than the HBO group. On immunohistochemical analysis, the ESWT group demonstrated significant increases in endothelial nitric oxide synthase, vessel endothelial growth factor, and proliferation cell nuclear antigen expressions and a decrease in transference-mediated digoxigenin-deoxy-UTP nick end-labeling expression than the HBO group. CONCLUSIONS: ESWT appears to be more effective than HBO in chronic diabetic foot ulcers.
Authors: Jae-Wook Chung; Tae Gyun Kwon; Se Won Jang; Eun Hye Lee; So Young Chun; Yun-Sok Ha; Seock Hwan Choi; Jun Nyung Lee; Bum Soo Kim; Hyun Tae Kim; See Hyung Kim; Tae-Hwan Kim; Eun Sang Yoo Journal: Int J Impot Res Date: 2022-03-28 Impact factor: 2.408
Authors: Paul A Butterworth; Tom P Walsh; Yvonne D Pennisi; Anna D Chesne; Christoph Schmitz; Susan A Nancarrow Journal: J Foot Ankle Res Date: 2015-02-05 Impact factor: 2.303
Authors: Sabrina Rohringer; Wolfgang Holnthoner; Matthias Hackl; Anna M Weihs; Dominik Rünzler; Susanna Skalicky; Michael Karbiener; Marcel Scheideler; Johannes Pröll; Christian Gabriel; Bernhard Schweighofer; Marion Gröger; Andreas Spittler; Johannes Grillari; Heinz Redl Journal: PLoS One Date: 2014-12-11 Impact factor: 3.240