| Literature DB >> 18619509 |
Isao Hamaguchi1, Jun-ichi Imai, Haruka Momose, Mika Kawamura, Takuo Mizukami, Seishiro Naito, Jun-ichi Maeyama, Atsuko Masumi, Madoka Kuramitsu, Kazuya Takizawa, Hiroshi Kato, Tetsuya Mizutani, Yoshinobu Horiuchi, Nobuo Nomura, Shinya Watanabe, Kazunari Yamaguchi.
Abstract
Although vaccines are routinely used to prevent infectious diseases, little is known about the comprehensive influences caused by vaccines. In this study, we showed, using comprehensive gene expression analysis, that pertussis vaccine affected many genes in multiple organs of vaccine-treated animals. In particular, lung was revealed to be the most suitable target to evaluate pertussis vaccine toxicity. The 13 genes identified from the analysis of vaccine-treated lung at day 1 showed a clear dendrogram corresponding to pertussis vaccine toxicity. Furthermore, quantitative analysis of these genes revealed a positive correlation between their respective expression levels and the degree of toxic effects observed in samples that had been treated with various doses of reference pertussis vaccines. The quantification of this 13 gene-set is an indicator of the vaccine toxicity-related reaction.Entities:
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Year: 2008 PMID： 18619509 DOI： 10.1016/j.vaccine.2008.06.086
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641