Literature DB >> 18619481

A rational nomenclature for naming peptide toxins from spiders and other venomous animals.

Glenn F King1, Margaret C Gentz, Pierre Escoubas, Graham M Nicholson.   

Abstract

Molecular toxinology research was initially driven by an interest in the small subset of animal toxins that are lethal to humans. However, the realization that many venomous creatures possess a complex repertoire of bioactive peptide toxins with potential pharmaceutical and agrochemical applications has led to an explosion in the number of new peptide toxins being discovered and characterized. Unfortunately, this increased awareness of peptide-toxin diversity has not been matched by the development of a generic nomenclature that enables these toxins to be rationally classified, catalogued, and compared. In this article, we introduce a rational nomenclature that can be applied to the naming of peptide toxins from spiders and other venomous animals.

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Year:  2008        PMID: 18619481     DOI: 10.1016/j.toxicon.2008.05.020

Source DB:  PubMed          Journal:  Toxicon        ISSN: 0041-0101            Impact factor:   3.033


  105 in total

1.  A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily.

Authors:  Mingyu Ye; Keith K Khoo; Shaoqiong Xu; Mi Zhou; Nonlawat Boonyalai; Matthew A Perugini; Xiaoxia Shao; Chengwu Chi; Charles A Galea; Chunguang Wang; Raymond S Norton
Journal:  J Biol Chem       Date:  2012-03-07       Impact factor: 5.157

2.  Hg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin family.

Authors:  Zong-Yun Chen; You-Tian Hu; Wei-Shan Yang; Ya-Wen He; Jing Feng; Bin Wang; Rui-Ming Zhao; Jiu-Ping Ding; Zhi-Jian Cao; Wen-Xin Li; Ying-Liang Wu
Journal:  J Biol Chem       Date:  2012-02-21       Impact factor: 5.157

3.  Venom: the sharp end of pain therapeutics.

Authors:  Steven A Trim; Carol M Trim
Journal:  Br J Pain       Date:  2013-11

4.  Naja atra venom peptide reduces pain by selectively blocking the voltage-gated sodium channel Nav1.8.

Authors:  Fan Zhang; Changxin Zhang; Xunxun Xu; Yunxiao Zhang; Xue Gong; Zuqin Yang; Heng Zhang; Dongfang Tang; Songping Liang; Zhonghua Liu
Journal:  J Biol Chem       Date:  2019-02-25       Impact factor: 5.157

5.  Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif.

Authors:  Jennifer J Smith; Justine M Hill; Michelle J Little; Graham M Nicholson; Glenn F King; Paul F Alewood
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-13       Impact factor: 11.205

6.  Synthesis, solution structure, and phylum selectivity of a spider delta-toxin that slows inactivation of specific voltage-gated sodium channel subtypes.

Authors:  Nahoko Yamaji; Michelle J Little; Hideki Nishio; Bert Billen; Elba Villegas; Yuji Nishiuchi; Jan Tytgat; Graham M Nicholson; Gerardo Corzo
Journal:  J Biol Chem       Date:  2009-07-10       Impact factor: 5.157

7.  Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the alpha1A-adrenoceptor.

Authors:  L Quinton; E Girard; A Maiga; M Rekik; P Lluel; G Masuyer; M Larregola; C Marquer; J Ciolek; T Magnin; R Wagner; J Molgó; R Thai; C Fruchart-Gaillard; G Mourier; J Chamot-Rooke; A Ménez; S Palea; D Servent; N Gilles
Journal:  Br J Pharmacol       Date:  2009-12-15       Impact factor: 8.739

8.  Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators.

Authors:  Volker Herzig; Kartik Sunagar; David T R Wilson; Sandy S Pineda; Mathilde R Israel; Sebastien Dutertre; Brianna Sollod McFarland; Eivind A B Undheim; Wayne C Hodgson; Paul F Alewood; Richard J Lewis; Frank Bosmans; Irina Vetter; Glenn F King; Bryan G Fry
Journal:  Proc Natl Acad Sci U S A       Date:  2020-09-21       Impact factor: 11.205

9.  The Terebridae and teretoxins: Combining phylogeny and anatomy for concerted discovery of bioactive compounds.

Authors:  Nicolas Puillandre; Mandë Holford
Journal:  BMC Chem Biol       Date:  2010-09-17

10.  ArachnoServer: a database of protein toxins from spiders.

Authors:  David L A Wood; Tomas Miljenović; Shuzhi Cai; Robert J Raven; Quentin Kaas; Pierre Escoubas; Volker Herzig; David Wilson; Glenn F King
Journal:  BMC Genomics       Date:  2009-08-13       Impact factor: 3.969

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