OBJECTIVE: To study the release of oleanolic acid loaded nanocapsules in vitro. METHODS: The rules of drug release in vitro from oleanolic acid loaded nanocapsules were observed by dynamic penetration system and HPLC. RESULTS: The profile curve of oleanolic acid loaded nanocapsules was fit for the Weibull equation. The release t(1/2) of oleanolic acid loaded nanocapsules was about 6.7 times as that of original oleanolic acid. CONCLUSION: Oleanolic acid loaded nanocapsules have obviously sustained effect.
OBJECTIVE: To study the release of oleanolic acid loaded nanocapsules in vitro. METHODS: The rules of drug release in vitro from oleanolic acid loaded nanocapsules were observed by dynamic penetration system and HPLC. RESULTS: The profile curve of oleanolic acid loaded nanocapsules was fit for the Weibull equation. The release t(1/2) of oleanolic acid loaded nanocapsules was about 6.7 times as that of original oleanolic acid. CONCLUSION:Oleanolic acid loaded nanocapsules have obviously sustained effect.
Authors: Catharina I Delebinski; Monika Twardziok; Susann Kleinsimon; Florian Hoff; Katharina Mulsow; Jana Rolff; Sebastian Jäger; Angelika Eggert; Georg Seifert Journal: PLoS One Date: 2015-08-05 Impact factor: 3.240