Literature DB >> 18618900

Total synthesis and stereochemical reassignment of tasiamide.

Zhen-Hua Ma1, Ni Song, Chun-Xia Li, Wei Zhang, Peng Wang, Ying-Xia Li.   

Abstract

The total synthesis of a marine acyclic peptide tasiamide and three diastereomers was reported for the first time. The synthesis has led to a reassignment of the N(alpha)-Me-L-Gln of tasiamide to be N(alpha)-Me-D-Gln, which was supported by 1H NMR, 13C NMR, COSY, HMQC, HMBC, and optical rotation. Copyright 2008 European Peptide Society and John Wiley & Sons, Ltd.

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Year:  2008        PMID: 18618900     DOI: 10.1002/psc.1051

Source DB:  PubMed          Journal:  J Pept Sci        ISSN: 1075-2617            Impact factor:   1.905


  2 in total

1.  Design, synthesis and biological evaluation of tasiamide analogues as tumor inhibitors.

Authors:  Wei Zhang; Tiantian Sun; Zhenhua Ma; Yingxia Li
Journal:  Mar Drugs       Date:  2014-04-22       Impact factor: 5.118

2.  Lipopeptides from the tropical marine cyanobacterium Symploca sp.

Authors:  Emily Mevers; F P Jake Haeckl; Paul D Boudreau; Tara Byrum; Pieter C Dorrestein; Frederick A Valeriote; William H Gerwick
Journal:  J Nat Prod       Date:  2014-03-03       Impact factor: 4.050

  2 in total

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