Literature DB >> 18618318

Oleanolic acid and related derivatives as medicinally important compounds.

Nighat Sultana1, Athar Ata.   

Abstract

Oleanolic acid has been isolated from chloroform extract of Olea ferruginea Royle after removal of organic bases and free acids. The literature survey revealed it to be biologically very important. In this review the biological significance of oleanolic acid and its derivatives has been discussed. The aim of this review is to update current knowledge on oleanolic acid and its natural and semisynthetic analogs, focussing on its cytotoxic, antitumer, antioxidant, anti-inflamatory, anti-HIV, acetyl cholinesterase, alpha-glucosidase, antimicrobial, hepatoprotective, anti-inflammatory, antipruritic, spasmolytic activity, anti-angiogenic, antiallergic, antiviral and immunomodulatory activities. We present in this review, for the first time, a compilation of the most relevant scientific papers and technical reports of the chemical, pre-clinical and clinical research on the properties of oleanolic acid and its derivatives.

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Year:  2008        PMID： 18618318     DOI： 10.1080/14756360701633187

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  32 in total

1.  Oleanane triterpenoids in the prevention and therapy of breast cancer: current evidence and future perspectives.

Authors:  Nisha R Parikh; Animesh Mandal; Deepak Bhatia; Kodappully Sivaraman Siveen; Gautam Sethi; Anupam Bishayee
Journal:  Phytochem Rev       Date:  2014-12       Impact factor: 5.374

2.  Efficient synthesis and biological evaluation of epiceanothic acid and related compounds.

Authors:  Pu Zhang; Li Xu; Keduo Qian; Jun Liu; Luyong Zhang; Kuo-Hsiung Lee; Hongbin Sun
Journal:  Bioorg Med Chem Lett       Date:  2010-11-05       Impact factor: 2.823

3.  Terpenoids as potential chemopreventive and therapeutic agents in liver cancer.

Authors:  Roslin J Thoppil; Anupam Bishayee
Journal:  World J Hepatol       Date:  2011-09-27

4.  Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.

Authors:  Xuechao Li; Yarong Song; Peng Zhang; Hongxue Zhu; Lifeng Chen; Yajun Xiao; Yifei Xing
Journal:  Tumour Biol       Date:  2015-12-18

Review 5.  Lowering serum lipids via PCSK9-targeting drugs: current advances and future perspectives.

Authors:  Ni-Ya He; Qing Li; Chun-Yan Wu; Zhong Ren; Ya Gao; Li-Hong Pan; Mei-Mei Wang; Hong-Yan Wen; Zhi-Sheng Jiang; Zhi-Han Tang; Lu-Shan Liu
Journal:  Acta Pharmacol Sin       Date:  2017-01-23       Impact factor: 6.150

Review 6.  Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents.

Authors:  Reen-Yen Kuo; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2009-08-13       Impact factor: 13.423

7.  Anti-inflammatory and membrane-stabilizing properties of two semisynthetic derivatives of oleanolic acid.

Authors:  Benedicta N Nkeh-Chungag; Opeoluwa O Oyedeji; Adebola O Oyedeji; Eugene J Ndebia
Journal:  Inflammation       Date:  2015-02       Impact factor: 4.092

8.  Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis.

Authors:  Animesh Mandal; Deepak Bhatia; Anupam Bishayee
Journal:  Mol Carcinog       Date:  2013-07-12       Impact factor: 4.784

Review 9.  Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer.

Authors:  Anupam Bishayee; Shamima Ahmed; Nikoleta Brankov; Marjorie Perloff
Journal:  Front Biosci (Landmark Ed)       Date:  2011-01-01

10.  Preventive Effect and Mechanism of Crossostephium chinense Extract on Balloon Angioplasty-Induced Neointimal Hyperplasia.

Authors:  Chun-Hsu Pan; Yu-Pei Lin; Jie-Yu Wang; Hui-Yu Huang; Shun-Cheng Huang; Ji-Mehng Lo; Chieh-Hsi Wu
Journal:  Evid Based Complement Alternat Med       Date:  2021-06-30       Impact factor: 2.629
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