| Literature DB >> 18617393 |
Giuseppe Perrone1, Pier Adelchi Ruffini, Vincenzo Catalano, Cathie Spino, Daniele Santini, Pietro Muretto, Chiara Spoto, Costantino Zingaretti, Valerio Sisti, Paolo Alessandroni, Paolo Giordani, Andrea Cicetti, Silvia D'Emidio, Sergio Morini, Annamaria Ruzzo, Mauro Magnani, Giuseppe Tonini, Carla Rabitti, Francesco Graziano.
Abstract
We investigated the clinical significance of tumour-infiltrating FOXP3-positive regulatory T cells (Tregs) in radically resected (R0) gastric cancer. From a single-institution database, tumors of 110 patients who underwent R0 resection for stage II-III disease were studied for FOXP3-positive Tregs by immunohistochemistry. The observed median number of FOXP3-positive Tregs was used as the cut-point in analyses (<6 versus >or=6 count). Tregs were significantly higher in gastric carcinomas than in normal tissue (P = 0.0001). Tregs count >or=6 was significantly associated with vascular/lymphatic/perineural invasion (VELIPI) in the tumour (P = 0.03). Multivariate analysis showed association between adverse relapse-free survival and grading 3, stage III, VELIPI and Tregs count >or=6 (P = 0.02). Adverse overall survival was associated with grading 3, stage III, VELIPI and Tregs count >or=6 (P = 0.006). FOXP3-positive Tregs may be a novel marker for identifying high-risk gastric cancer patients. Present findings deserve additional investigation as Tregs may also represent an innovative therapeutic target.Entities:
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Year: 2008 PMID： 18617393 DOI： 10.1016/j.ejca.2008.05.017
Source DB: PubMed Journal: Eur J Cancer ISSN： 0959-8049 Impact factor: 9.162