Literature DB >> 18617323

Mechanism of anticancer activity of buforin IIb, a histone H2A-derived peptide.

Hyun Soo Lee1, Chan Bae Park, Jung Min Kim, Su A Jang, In Yup Park, Mi Sun Kim, Ju Hyun Cho, Sun Chang Kim.   

Abstract

Buforin IIb is a novel cell-penetrating anticancer peptide derived from histone H2A. Here we analyzed the anticancer activity and cancer cell-killing mechanism of buforin IIb. Buforin IIb displayed selective cytotoxicity against 62 cancer cell lines by specifically targeting cancer cells through interaction with cell surface gangliosides. It traversed cancer cell membranes without damaging them and accumulated primarily in the nuclei. Once inside the cells, buforin IIb induced mitochondria-dependent apoptosis. In vivo analysis revealed that buforin IIb displayed significant tumor suppression activity in mice with tumor xenograft. Overall, these results suggest that buforin IIb constitutes a novel therapeutic agent for the treatment of cancers.

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Year:  2008        PMID： 18617323     DOI： 10.1016/j.canlet.2008.05.041

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  42 in total

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