Literature DB >> 1861720

Multiple modes of engrailed regulation in the progression towards cell fate determination.

J Heemskerk1, S DiNardo, R Kostriken, P H O'Farrell.   

Abstract

The engrailed gene product of Drosophila specifies the fate of a subset of cells in each segment. Our studies of engrailed regulation suggest that fate determination is an elaborate, multistep process. At the time in embryogenesis when the engrailed-dependent cell fate is probably determined, four modes of control act in an overlapping progression to govern engrailed expression. After activation by pair-rule genes, both an extracellular signal, wingless, and autoregulation are required for engrailed expression. Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed-independent mode of maintenance.

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Mesh：

Year:  1991        PMID： 1861720      PMCID： PMC2755087          DOI： 10.1038/352404a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  30 in total

1.  Compartments in the wing of Drosophila: a study of the engrailed gene.

Authors:  P A Lawrence; G Morata
Journal:  Dev Biol       Date:  1976-06       Impact factor: 3.582

2.  Transposition of cloned P elements into Drosophila germ line chromosomes.

Authors:  A C Spradling; G M Rubin
Journal:  Science       Date:  1982-10-22       Impact factor: 47.728

3.  The engrailed locus of Drosophila: structural analysis of an embryonic transcript.

Authors:  S J Poole; L M Kauvar; B Drees; T Kornberg
Journal:  Cell       Date:  1985-01       Impact factor: 41.582

4.  The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless.

Authors:  F Rijsewijk; M Schuermann; E Wagenaar; P Parren; D Weigel; R Nusse
Journal:  Cell       Date:  1987-08-14       Impact factor: 41.582

5.  Engrailed: a gene controlling compartment and segment formation in Drosophila.

Authors:  T Kornberg
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205

6.  Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm.

Authors:  K Howard; P Ingham
Journal:  Cell       Date:  1986-03-28       Impact factor: 41.582

7.  Molecular cloning of sequences from wingless, a segment polarity gene in Drosophila: the spatial distribution of a transcript in embryos.

Authors:  N E Baker
Journal:  EMBO J       Date:  1987-06       Impact factor: 11.598

8.  Localization of transcripts from the wingless gene in whole Drosophila embryos.

Authors:  N E Baker
Journal:  Development       Date:  1988-06       Impact factor: 6.868

9.  Modifying expression of the engrailed gene of Drosophila melanogaster.

Authors:  S J Poole; T B Kornberg
Journal:  Development       Date:  1988       Impact factor: 6.868

10.  Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila.

Authors:  G Struhl; M Akam
Journal:  EMBO J       Date:  1985-12-01       Impact factor: 11.598
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  55 in total

Review 1.  Generating patterns from fields of cells. Examples from Drosophila segmentation.

Authors:  B Sanson
Journal:  EMBO Rep       Date:  2001-12       Impact factor: 8.807

2.  eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins.

Authors:  J E Treisman; A Luk; G M Rubin; U Heberlein
Journal:  Genes Dev       Date:  1997-08-01       Impact factor: 11.361

3.  Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila.

Authors:  Masatomo Kobayashi; Miki Fujioka; Elena N Tolkunova; Deepali Deka; Muna Abu-Shaar; Richard S Mann; James B Jaynes
Journal:  Development       Date:  2003-02       Impact factor: 6.868

4.  Drawing lines in the sand: even skipped et al. and parasegment boundaries.

Authors:  James B Jaynes; Miki Fujioka
Journal:  Dev Biol       Date:  2004-05-15       Impact factor: 3.582

5.  The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells.

Authors:  S F Jue; R S Bradley; J A Rudnicki; H E Varmus; A M Brown
Journal:  Mol Cell Biol       Date:  1992-01       Impact factor: 4.272

6.  Engrailed cooperates directly with Extradenticle and Homothorax on a distinct class of homeodomain binding sites to repress sloppy paired.

Authors:  Miki Fujioka; Brian Gebelein; Zenobia C Cofer; Richard S Mann; James B Jaynes
Journal:  Dev Biol       Date:  2012-04-20       Impact factor: 3.582

7.  Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-cell factors.

Authors:  Simon Wöhrle; Britta Wallmen; Andreas Hecht
Journal:  Mol Cell Biol       Date:  2007-10-08       Impact factor: 4.272

8.  The Drosophila engrailed and invected genes: partners in regulation, expression and function.

Authors:  E Gustavson; A S Goldsborough; Z Ali; T B Kornberg
Journal:  Genetics       Date:  1996-03       Impact factor: 4.562

9.  Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster.

Authors:  D C Slusarski; C K Motzny; R Holmgren
Journal:  Genetics       Date:  1995-01       Impact factor: 4.562

10.  The state of engrailed expression is not clonally transmitted during early Drosophila development.

Authors:  J P Vincent; P H O'Farrell
Journal:  Cell       Date:  1992-03-06       Impact factor: 41.582
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