| Literature DB >> 18616322 |
Luiz C Dias1, Anderson A de Marchi, Marco A B Ferreira, Andrea M Aguilar.
Abstract
Good levels of substrate-controlled, 1,5- syn-stereoinduction are obtained in boron-mediated aldol reactions of beta-trichloromethyl-beta-alkoxy and beta-trifluoromethyl-beta-alkoxy methylketones with achiral aldehydes, independent of the nature of the beta-alkoxy protecting group (TBS or PMB). In the case of boron aldol reactions of beta-aryl-beta-alkoxy methylketones, the 1,5- anti-adducts were obtained with high levels of diastereoselectivity only with a beta-OPMB group.Entities:
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Year: 2008 PMID： 18616322 DOI： 10.1021/jo8009165
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354