Heide Lingard1, Sonja Zehetmayer, Manfred Maier. 1. Department of General Practice and Family Medicine, Medical University, Vienna, Austria. heide.lingard@meduniwien.ac.at
Abstract
OBJECTIVE: The aim of this study was to estimate the rate of bacterial superinfection in patients with URTI by using on-site determination of C-reactive protein (CRP). DESIGN: A prospective cohort study. SETTING: A total of 30 primary care practices. SUBJECTS: Patients with URTI. INTERVENTION: The CRP value was determined at the first consultation and at a follow-up within 3-5 days. CRP values of 30 units (mg) or higher were considered to be an indication of bacterial involvement. MAIN OUTCOME MEASURES: CRP values during follow-up and duration of illness. RESULTS: Among the 506 patients included, 73.1% exhibited a CRP value below the defined limit at their first visit and were considered to suffer from URTI of viral origin. The rate of subsequent bacterial superinfection was 8.1%. Compared with patients suffering from URTI of bacterial or viral origin the duration of illness in patients with bacterial superinfection was significantly longer. CONCLUSION: During follow-up of patients with URTI, the prevalence of bacterial superinfection detected by using a near patient CRP determination is surprisingly low. This result should help to reduce the prescription rate of antibiotics in primary care.
OBJECTIVE: The aim of this study was to estimate the rate of bacterial superinfection in patients with URTI by using on-site determination of C-reactive protein (CRP). DESIGN: A prospective cohort study. SETTING: A total of 30 primary care practices. SUBJECTS:Patients with URTI. INTERVENTION: The CRP value was determined at the first consultation and at a follow-up within 3-5 days. CRP values of 30 units (mg) or higher were considered to be an indication of bacterial involvement. MAIN OUTCOME MEASURES: CRP values during follow-up and duration of illness. RESULTS: Among the 506 patients included, 73.1% exhibited a CRP value below the defined limit at their first visit and were considered to suffer from URTI of viral origin. The rate of subsequent bacterial superinfection was 8.1%. Compared with patients suffering from URTI of bacterial or viral origin the duration of illness in patients with bacterial superinfection was significantly longer. CONCLUSION: During follow-up of patients with URTI, the prevalence of bacterial superinfection detected by using a near patientCRP determination is surprisingly low. This result should help to reduce the prescription rate of antibiotics in primary care.
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Authors: Ngo Ngoc Quang Minh; Pham Van Toi; Le Minh Qui; Le Binh Bao Tinh; Nguyen Thi Ngoc; Le Thi Ngoc Kim; Nguyen Hanh Uyen; Vu Thi Ty Hang; Nguyen Thi Thuy Chinh B'Krong; Nguyen Thi Tham; Thai Dang Khoa; Huynh Duy Khuong; Pham Quynh Vi; Nguyen Ngoc Hong Phuc; Le Thi Minh Vien; Thomas Pouplin; Doan Van Khanh; Pham Nguyen Phuong; Phung Khanh Lam; Heiman F L Wertheim; James I Campbell; Stephen Baker; Christopher M Parry; Juliet E Bryant; Constance Schultsz; Nguyen Thanh Hung; Menno D de Jong; H Rogier van Doorn Journal: PLoS One Date: 2020-11-04 Impact factor: 3.240