Literature DB >> 18614365

Successful kinase bypass with new acyclovir phosphoramidate prodrugs.

Christopher McGuigan1, Marco Derudas, Joachim J Bugert, Graciela Andrei, Robert Snoeck, Jan Balzarini.   

Abstract

Novel phosphoramidates of acyclovir have been prepared and evaluated in vitro against acyclovir-sensitive and -resistant herpes simplex virus (HSV) types 1 and 2 and varicella-zoster virus (VZV). Unlike the parent nucleoside these novel phosphate prodrugs retain antiviral potency versus the ACV-resistant virus strain, suggesting an efficient bypass of the viral thymidine kinase.

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Year:  2008        PMID： 18614365     DOI： 10.1016/j.bmcl.2008.06.069

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

Review 1.  Synthesis of nucleoside phosphate and phosphonate prodrugs.

Authors:  Ugo Pradere; Ethel C Garnier-Amblard; Steven J Coats; Franck Amblard; Raymond F Schinazi
Journal:  Chem Rev       Date:  2014-08-21       Impact factor: 60.622

2.  Virtual Screening of Acyclovir Derivatives as Potential Antiviral Agents: Design, Synthesis, and Biological Evaluation of New Acyclic Nucleoside ProTides.

Authors:  Marco Derudas; Christophe Vanpouille; Davide Carta; Sonia Zicari; Graciela Andrei; Robert Snoeck; Andrea Brancale; Leonid Margolis; Jan Balzarini; Christopher McGuigan
Journal:  J Med Chem       Date:  2017-09-19       Impact factor: 7.446

3.  A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2.

Authors:  Christophe Vanpouille; Andrea Lisco; Marco Derudas; Elisa Saba; Jean-Charles Grivel; Beda Brichacek; Francesca Scrimieri; Raymond Schinazi; Dominique Schols; Christopher McGuigan; Jan Balzarini; Leonid Margolis
Journal:  J Infect Dis       Date:  2010-02-15       Impact factor: 5.226

4.  The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition.

Authors:  Marco Derudas; Davide Carta; Andrea Brancale; Christophe Vanpouille; Andrea Lisco; Leonid Margolis; Jan Balzarini; Christopher McGuigan
Journal:  J Med Chem       Date:  2009-09-10       Impact factor: 7.446

5.  Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase.

Authors:  Egor P Tchesnokov; Aleksandr Obikhod; Ivana Massud; Andrea Lisco; Christophe Vanpouille; Beda Brichacek; Jan Balzarini; Christopher McGuigan; Marco Derudas; Leonid Margolis; Raymond F Schinazi; Matthias Götte
Journal:  J Biol Chem       Date:  2009-06-09       Impact factor: 5.157

Review 6.  Phosphoramidates and phosphonamidates (ProTides) with antiviral activity.

Authors:  Magdalena Slusarczyk; Michaela Serpi; Fabrizio Pertusati
Journal:  Antivir Chem Chemother       Date:  2018 Jan-Dec

7.  Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin.

Authors:  Marco Derudas; Andrea Brancale; Lieve Naesens; Johan Neyts; Jan Balzarini; Christopher McGuigan
Journal:  Bioorg Med Chem       Date:  2010-02-15       Impact factor: 3.641
  7 in total

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