Literature DB >> 18614042

mTOR and Akt signaling in cancer: SGK cycles in.

Alex Toker1.   

Abstract

In a recent issue of Molecular Cell, Hong et al. (2008) describe an alternative mechanism by which mTOR promotes cell-cycle progression; it phosphorylates and activates SGK, which in turn phosphorylates the cell-cycle inhibitor p27, promoting its cytoplasmic retention.

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Year:  2008        PMID： 18614042     DOI： 10.1016/j.molcel.2008.06.007

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  9 in total

1.  Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway.

Authors:  Donggon Lyo; Limei Xu; David A Foster
Journal:  Biochem Biophys Res Commun       Date:  2010-05-08       Impact factor: 3.575

2.  Activation of mTORC1 in collecting ducts causes hyperkalemia.

Authors:  Zhenguo Chen; Heling Dong; Chunhong Jia; Qiancheng Song; Juan Chen; Yue Zhang; Pinglin Lai; Xiaorong Fan; Xuan Zhou; Miao Liu; Jun Lin; Cuilan Yang; Ming Li; Tianming Gao; Xiaochun Bai
Journal:  J Am Soc Nephrol       Date:  2013-11-07       Impact factor: 10.121

3.  Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells.

Authors:  Joby J Westmoreland; Qian Wang; Mohamed Bouzaffour; Suzanne J Baker; Beatriz Sosa-Pineda
Journal:  Dev Biol       Date:  2009-07-25       Impact factor: 3.582

Review 4.  The role of PI3'-lipid signalling in melanoma initiation, progression and maintenance.

Authors:  Gennie L Parkman; Mona Foth; David A Kircher; Sheri L Holmen; Martin McMahon
Journal:  Exp Dermatol       Date:  2021-11-09       Impact factor: 3.960

5.  Be quiet and you'll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence?

Authors:  Vjekoslav Dulic
Journal:  Aging (Albany NY)       Date:  2011-01       Impact factor: 5.682

6.  Identification of protein features encoded by alternative exons using Exon Ontology.

Authors:  Léon-Charles Tranchevent; Fabien Aubé; Louis Dulaurier; Clara Benoit-Pilven; Amandine Rey; Arnaud Poret; Emilie Chautard; Hussein Mortada; François-Olivier Desmet; Fatima Zahra Chakrama; Maira Alejandra Moreno-Garcia; Evelyne Goillot; Stéphane Janczarski; Franck Mortreux; Cyril F Bourgeois; Didier Auboeuf
Journal:  Genome Res       Date:  2017-04-18       Impact factor: 9.043

7.  mir15a/mir16-1 cluster and its novel targeting molecules negatively regulate cardiac hypertrophy.

Authors:  Hongchang Guo; Ke Ma; Wenjing Hao; Yao Jiao; Ping Li; Jing Chen; Chen Xu; Fu-Jian Xu; Wayne Bond Lau; Jie Du; Xin-Liang Ma; Yulin Li
Journal:  Clin Transl Med       Date:  2020-12

8.  HPV E7-mediated NCAPH ectopic expression regulates the carcinogenesis of cervical carcinoma via PI3K/AKT/SGK pathway.

Authors:  Meng Wang; Xiaowen Qiao; Tamara Cooper; Wei Pan; Liang Liu; John Hayball; Jiaxiang Lin; Xiujie Cui; Yabin Zhou; Shule Zhang; Ying Zou; Ranran Zhang; Xiao Wang
Journal:  Cell Death Dis       Date:  2020-12-11       Impact factor: 8.469

9.  Combination of gefitinib and DNA methylation inhibitor decitabine exerts synergistic anti-cancer activity in colon cancer cells.

Authors:  Yun-feng Lou; Zheng-zhi Zou; Pin-jia Chen; Guo-bin Huang; Bin Li; De-qing Zheng; Xiu-rong Yu; Xiao-yong Luo
Journal:  PLoS One       Date:  2014-05-29       Impact factor: 3.240
  9 in total

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