BACKGROUND: Defibrotide is a deoxyribonucleic acid derivative that has been developed for the treatment of different vascular disorders. OBJECTIVE: The authors reviewed the literature to give due representation to the spectrum of pharmacological properties and clinical application of this drug, evaluating consolidate and innovative application. METHODS: The authors used PubMed from November 1982 to December 2007 and meeting abstracts (form American Society of Hematology Annual Meeting) with updated data as the sources for this review and selecting the most relevant papers when two or more articles covered the same point of interest. CONCLUSIONS: Defibrotide has been used effectively in the treatment of endothelial complications of allogeneic stem cell transplantation and recent preclinical evidences suggest an antiangiogenic effect and an anticancer activity. Further in vivo and in vitro investigations are needed.
BACKGROUND:Defibrotide is a deoxyribonucleic acid derivative that has been developed for the treatment of different vascular disorders. OBJECTIVE: The authors reviewed the literature to give due representation to the spectrum of pharmacological properties and clinical application of this drug, evaluating consolidate and innovative application. METHODS: The authors used PubMed from November 1982 to December 2007 and meeting abstracts (form American Society of Hematology Annual Meeting) with updated data as the sources for this review and selecting the most relevant papers when two or more articles covered the same point of interest. CONCLUSIONS:Defibrotide has been used effectively in the treatment of endothelial complications of allogeneic stem cell transplantation and recent preclinical evidences suggest an antiangiogenic effect and an anticancer activity. Further in vivo and in vitro investigations are needed.
Authors: Ivo M B Francischetti; Carlo J Oliveira; Graciela R Ostera; Stephanie B Yager; Françoise Debierre-Grockiego; Vanessa Carregaro; Giovanna Jaramillo-Gutierrez; Jen C C Hume; Lubin Jiang; Samuel E Moretz; Christina K Lin; José M C Ribeiro; Carole A Long; Brandi K Vickers; Ralph T Schwarz; Karl B Seydel; Massimo Iacobelli; Hans C Ackerman; Prakash Srinivasan; Regis B Gomes; Xunde Wang; Robson Q Monteiro; Michail Kotsyfakis; Anderson Sá-Nunes; Michael Waisberg Journal: Arterioscler Thromb Vasc Biol Date: 2011-11-23 Impact factor: 8.311
Authors: John W Avery; Geoffrey M Smith; Simon O Owino; Demba Sarr; Tamas Nagy; Stephen Mwalimu; James Matthias; Lauren F Kelly; Jayakumar S Poovassery; Joab D Middii; Carlos Abramowsky; Julie M Moore Journal: PLoS One Date: 2012-02-07 Impact factor: 3.240