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Literature DB >> 18613709

Double emulsion templated monodisperse phospholipid vesicles.

Ho Cheung Shum¹, Daeyeon Lee, Insun Yoon, Tom Kodger, David A Weitz.

Abstract

We present a novel approach for fabricating monodisperse phospholipid vesicles with high encapsulation efficiency using controlled double emulsions as templates. Glass-capillary microfluidics is used to generate monodisperse double emulsion templates. We show that the high uniformity in size and shape of the templates are maintained in the final phospholipid vesicles after a solvent removal step. Our simple and versatile technique is applicable to a wide range of phospholipids.

Entities: Chemical

Mesh：

Substances：
Emulsions
Phospholipids

Year: 2008 PMID： 18613709 DOI： 10.1021/la801833a

Source DB: PubMed Journal: Langmuir ISSN： 0743-7463 Impact factor: 3.882

Keyword Cloud
Cited

44 in total

1. Stable, biocompatible lipid vesicle generation by solvent extraction-based droplet microfluidics.

Authors: Shia-Yen Teh; Ruba Khnouf; Hugh Fan; Abraham P Lee
Journal: Biomicrofluidics Date: 2011-12-09 Impact factor: 2.800

2. Microfluidic fabrication of water-in-water (w/w) jets and emulsions.

Authors: Ho Cheung Shum; Jason Varnell; David A Weitz
Journal: Biomicrofluidics Date: 2012-03-15 Impact factor: 2.800

3. Droplet based microfluidic fabrication of designer microparticles for encapsulation applications.

Authors: Tiantian Kong; Jun Wu; Michael To; Kelvin Wai Kwok Yeung; Ho Cheung Shum; Liqiu Wang
Journal: Biomicrofluidics Date: 2012-07-20 Impact factor: 2.800

4. An "off-the-shelf" capillary microfluidic device that enables tuning of the droplet breakup regime at constant flow rates.

Authors: Bryan R Benson; Howard A Stone; Robert K Prud'homme
Journal: Lab Chip Date: 2013-12-07 Impact factor: 6.799

Double emulsion templated monodisperse phospholipid vesicles.

1. Stable, biocompatible lipid vesicle generation by solvent extraction-based droplet microfluidics.

2. Microfluidic fabrication of water-in-water (w/w) jets and emulsions.

3. Droplet based microfluidic fabrication of designer microparticles for encapsulation applications.

4. An "off-the-shelf" capillary microfluidic device that enables tuning of the droplet breakup regime at constant flow rates.

5. Inkjet formation of unilamellar lipid vesicles for cell-like encapsulation.

6. Forming and loading giant unilamellar vesicles with acoustic jetting.

7. Liquid-liquid phase separation in artificial cells.

8. Lipid bilayer vesicle generation using microfluidic jetting.

9. Engineering artificial cells by combining HeLa-based cell-free expression and ultrathin double emulsion template.

10. Enzymatically triggered rupture of polymersomes.