Literature DB >> 18613163

Enabling continuous-flow chemistry in microstructured devices for pharmaceutical and fine-chemical production.

Norbert Kockmann1, Michael Gottsponer, Bertin Zimmermann, Dominique M Roberge.   

Abstract

Microstructured devices offer unique transport capabilities for rapid mixing, enhanced heat and mass transfer and can handle small amounts of dangerous or unstable materials. The integration of reaction kinetics into fluid dynamics and transport phenomena is essential for successful application from process design in laboratory to chemical production. Strategies to implement production campaigns up to tons of pharmaceutical chemicals are discussed, based on Lonza projects.

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Year:  2008        PMID： 18613163     DOI： 10.1002/chem.200800707

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  8 in total

Review 1.  The past, present and potential for microfluidic reactor technology in chemical synthesis.

Authors:  Katherine S Elvira; Xavier Casadevall i Solvas; Robert C R Wootton; Andrew J deMello
Journal:  Nat Chem       Date:  2013-10-13       Impact factor: 24.427

2.  A flow-microreactor approach to protecting-group-free synthesis using organolithium compounds.

Authors:  Heejin Kim; Aiichiro Nagaki; Jun-ichi Yoshida
Journal:  Nat Commun       Date:  2011       Impact factor: 14.919

3.  Continuous-flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyproline.

Authors:  Xacobe C Cambeiro; Rafael Martín-Rapún; Pedro O Miranda; Sonia Sayalero; Esther Alza; Patricia Llanes; Miquel A Pericàs
Journal:  Beilstein J Org Chem       Date:  2011-10-31       Impact factor: 2.883

4.  Biocatalysis in Continuous-Flow Microfluidic Reactors.

Authors:  Marco P Cardoso Marques; Alvaro Lorente-Arevalo; Juan M Bolivar
Journal:  Adv Biochem Eng Biotechnol       Date:  2022       Impact factor: 2.768

5.  Generation and Trapping of Ketenes in Flow.

Authors:  Cyril Henry; David Bolien; Bogdan Ibanescu; Sally Bloodworth; David C Harrowven; Xunli Zhang; Andy Craven; Helen F Sneddon; Richard J Whitby
Journal:  European J Org Chem       Date:  2015-01-20

Review 6.  Continuous-flow processes for the catalytic partial hydrogenation reaction of alkynes.

Authors:  Carmen Moreno-Marrodan; Francesca Liguori; Pierluigi Barbaro
Journal:  Beilstein J Org Chem       Date:  2017-04-20       Impact factor: 2.883

7.  Mass spectrometric directed system for the continuous-flow synthesis and purification of diphenhydramine.

Authors:  Bradley P Loren; Michael Wleklinski; Andy Koswara; Kathryn Yammine; Yanyang Hu; Zoltan K Nagy; David H Thompson; R Graham Cooks
Journal:  Chem Sci       Date:  2017-04-19       Impact factor: 9.825

8.  Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor.

Authors:  Balázs Decsi; Réka Krammer; Kristóf Hegedűs; Ferenc Ender; Benjámin Gyarmati; András Szilágyi; Róbert Tőtős; Gabriel Katona; Csaba Paizs; György T Balogh; László Poppe; Diána Balogh-Weiser
Journal:  Micromachines (Basel)       Date:  2019-10-01       Impact factor: 2.891
  8 in total

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