OBJECTIVES: The correlation of immune activation with CD4(+) depletion and HIV-1 disease progression has been evidenced by several studies involving mainly clade B virus. However, this needs to be investigated in developing countries such as India predominately infected with clade C virus. MATERIALS AND METHODS: In a cross-sectional study of 68 antiretroviral treatment naïve, HIV-1 infected Indian patients, we studied the association between CD4(+) T cells, plasma HIV-1 RNA levels, and immune activation markers using unadjusted and adjusted correlative analyses. RESULTS: Significant negative correlations of higher magnitude were observed between the CD4(+) T cell percentages and plasma HIV-1 RNA levels in the study population when adjusted for the effects of immune activation markers. However, the negative association of CD4(+) T cells with immune activation markers remained unaffected when controlled for the effects of plasma HIV-1 RNA levels. CONCLUSIONS: Our results support the important role of immune activation in CD4(+) T cell depletion and disease progression during untreated HIV-1 infection.
OBJECTIVES: The correlation of immune activation with CD4(+) depletion and HIV-1 disease progression has been evidenced by several studies involving mainly clade B virus. However, this needs to be investigated in developing countries such as India predominately infected with clade C virus. MATERIALS AND METHODS: In a cross-sectional study of 68 antiretroviral treatment naïve, HIV-1 infected Indian patients, we studied the association between CD4(+) T cells, plasma HIV-1 RNA levels, and immune activation markers using unadjusted and adjusted correlative analyses. RESULTS: Significant negative correlations of higher magnitude were observed between the CD4(+) T cell percentages and plasma HIV-1 RNA levels in the study population when adjusted for the effects of immune activation markers. However, the negative association of CD4(+) T cells with immune activation markers remained unaffected when controlled for the effects of plasma HIV-1 RNA levels. CONCLUSIONS: Our results support the important role of immune activation in CD4(+) T cell depletion and disease progression during untreated HIV-1 infection.
Authors: A Mocroft; M Bofill; M Lipman; E Medina; N Borthwick; A Timms; L Batista; M Winter; C A Sabin; M Johnson; C A Lee; A Phillips; G Janossy Journal: J Acquir Immune Defic Syndr Hum Retrovirol Date: 1997-02-01
Authors: J W Cohen Stuart; M D Hazebergh; D Hamann; S A Otto; J C Borleffs; F Miedema; C A Boucher; R J de Boer Journal: J Acquir Immune Defic Syndr Date: 2000-11-01 Impact factor: 3.731
Authors: Ana E Sousa; Jorge Carneiro; Martin Meier-Schellersheim; Zvi Grossman; Rui M M Victorino Journal: J Immunol Date: 2002-09-15 Impact factor: 5.422
Authors: Jason M Brenchley; Timothy W Schacker; Laura E Ruff; David A Price; Jodie H Taylor; Gregory J Beilman; Phuong L Nguyen; Alexander Khoruts; Matthew Larson; Ashley T Haase; Daniel C Douek Journal: J Exp Med Date: 2004-09-13 Impact factor: 14.307