BACKGROUND: South Asians (SAs) have a higher prevalence of coronary artery disease than Caucasians. The long-term prognosis following acute coronary syndromes (ACS) in SA compared with non-SA patients is unclear. OBJECTIVES: To compare the long-term adverse cardiovascular outcomes between SA and non-SA patients who have ACS. METHODS: A case-control study of 65 consecutive SA patients admitted with ACS to the McGill University Health Centre (Montreal, Quebec) between 1995 and 2000 was conducted. Control subjects included 65 non-SA patients admitted to the same hospital with ACS matched by age, sex and year of hospitalization. RESULTS: The mean +/- SD age was 59.7+/-9.9 years and 12% of patients were women. There were more cases of diabetes mellitus among the SA patients than non-SA patients (43% versus 23%, respectively). Only 19% of SA patients were active smokers, compared with 34% of non-SA patients. At one year, 35% of SA patients had undergone coronary artery bypass graft surgery, compared with 22% of non-SA patients. One-year mortality was increased among the SA patients compared with the non-SA patients (6% versus 2%, respectively). However, SA ethnicity was not an independent predictor of one-year adverse cardiovascular outcomes. CONCLUSIONS: The present study demonstrated an increased prevalence of diabetes mellitus among the SA patients with ACS compared with non-SA patients. SA patients had increased one-year mortality compared with non-SA patients. However, SA ethnicity was not an independent predictor of one-year mortality and coronary intervention.
BACKGROUND: South Asians (SAs) have a higher prevalence of coronary artery disease than Caucasians. The long-term prognosis following acute coronary syndromes (ACS) in SA compared with non-SApatients is unclear. OBJECTIVES: To compare the long-term adverse cardiovascular outcomes between SA and non-SApatients who have ACS. METHODS: A case-control study of 65 consecutive SApatients admitted with ACS to the McGill University Health Centre (Montreal, Quebec) between 1995 and 2000 was conducted. Control subjects included 65 non-SApatients admitted to the same hospital with ACS matched by age, sex and year of hospitalization. RESULTS: The mean +/- SD age was 59.7+/-9.9 years and 12% of patients were women. There were more cases of diabetes mellitus among the SApatients than non-SApatients (43% versus 23%, respectively). Only 19% of SApatients were active smokers, compared with 34% of non-SApatients. At one year, 35% of SApatients had undergone coronary artery bypass graft surgery, compared with 22% of non-SApatients. One-year mortality was increased among the SApatients compared with the non-SApatients (6% versus 2%, respectively). However, SA ethnicity was not an independent predictor of one-year adverse cardiovascular outcomes. CONCLUSIONS: The present study demonstrated an increased prevalence of diabetes mellitus among the SApatients with ACS compared with non-SApatients. SApatients had increased one-year mortality compared with non-SApatients. However, SA ethnicity was not an independent predictor of one-year mortality and coronary intervention.
Authors: C P Cannon; W S Weintraub; L A Demopoulos; R Vicari; M J Frey; N Lakkis; F J Neumann; D H Robertson; P T DeLucca; P M DiBattiste; C M Gibson; E Braunwald Journal: N Engl J Med Date: 2001-06-21 Impact factor: 91.245
Authors: S S Anand; S Yusuf; V Vuksan; S Devanesen; K K Teo; P A Montague; L Kelemen; C Yi; E Lonn; H Gerstein; R A Hegele; M McQueen Journal: Lancet Date: 2000-07-22 Impact factor: 79.321