Cefpodoxime proxetil: a comprehensive review.

Cefpodoxime proxetil, a relatively new broad-spectrum third-generaation cephalosporin, has very good in vitro activity against Enterobacteriaceae, Hemophilus spp. and Moraxella spp., including beta-lactamase producers and many strains resistant to other oral agents. It also has activity against Gram-positive bacteria, especially against streptococci. Cefpodoxime has no activity against enterococci. It is well tolerated and is one of the first third-generation cephalosporins to be available in oral form. While the compound has been used most widely in the treatment of respiratory and urinary tract infections, its utility has also been demonstrated in the treatment of skin structure infections, acute otitis media, pharyngitis, tonsillitis, and sexually transmitted diseases.