| Literature DB >> 18611055 |
Anton Agarkov1, Scott R Gilbertson.
Abstract
This paper reports the preparation of a library of unsymmetrical ureas based on 8-azabicyclo[3.2.1]octane scaffold. The reported synthetic route uses nortropane-8-carbonyl chlorides as key intermediates that, when treated with a slight excess of amine, give the corresponding ureas in high yield (129 examples).Entities:
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Year: 2008 PMID： 18611055 PMCID： PMC3086471 DOI： 10.1021/cc800068k
Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766