Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The biological role of chondroitin sulfate in cancer and chondroitin-based anticancer agents.

Literature DB >> 18610752

The biological role of chondroitin sulfate in cancer and chondroitin-based anticancer agents.

Athanasia P Asimakopoulou¹, Achilleas D Theocharis, George N Tzanakakis, Nikos K Karamanos.

Abstract

Chondroitin sulfate proteoglycans (CSPGs) such as versican accumulate in tumor stroma and play a key role in tumor growth and invasion. The high expression of CSPGs in fast growing tissues and cells is correlated with chondroitin sulfate (CS) chains and the sulfation pattern. The negatively charged CS chains interact with a large number of ligands and receptors and activate signalling pathways which stimulate tumor growth. However, the role of chondroitin sulfate in cancer promotion seems to be controversial, as recent studies support the use of modified CS as a potent anticancer agent. In this review, the biological roles of CSPGs in cancer and the anticancer effects of modified CS are presented and discussed.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2008 PMID： 18610752

Source DB: PubMed Journal: In Vivo ISSN： 0258-851X Impact factor: 2.155

Keyword Cloud
Cited

32 in total

1. Humanized chondroitinase ABC sensitizes glioblastoma cells to temozolomide.

Authors: Alena Cristina Jaime-Ramirez; Nina Dmitrieva; Ji Young Yoo; Yeshavanth Banasavadi-Siddegowda; Jianying Zhang; Theresa Relation; Chelsea Bolyard; Jeffrey Wojton; Balveen Kaur
Journal: J Gene Med Date: 2017-03 Impact factor: 4.565

2. Chondroitin sulfate as a molecular portal that preferentially mediates the apoptotic killing of tumor cells by penetratin-directed mitochondria-disrupting peptides.

Authors: Hao Yang; Shan Liu; Huawei Cai; Lin Wan; Shengfu Li; Youping Li; Jingqiu Cheng; Xiaofeng Lu
Journal: J Biol Chem Date: 2010-05-18 Impact factor: 5.157

3. MDA-MB-231 breast cancer cell viability, motility and matrix adhesion are regulated by a complex interplay of heparan sulfate, chondroitin-/dermatan sulfate and hyaluronan biosynthesis.

Authors: Manuela Viola; Kathrin Brüggemann; Evgenia Karousou; Ilaria Caon; Elena Caravà; Davide Vigetti; Burkhard Greve; Christian Stock; Giancarlo De Luca; Alberto Passi; Martin Götte
Journal: Glycoconj J Date: 2016-10-15 Impact factor: 2.916

4. Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development.

Authors: James Melrose; Marc D Isaacs; Susan M Smith; Clare E Hughes; Christopher B Little; Bruce Caterson; Anthony J Hayes
Journal: Histochem Cell Biol Date: 2012-05-23 Impact factor: 4.304

5. Efficient secretion of biologically active Chondroitinase ABC from mammalian cells in the absence of an N-terminal signal peptide.

Authors: Michael Klüppel
Journal: Mol Cell Biochem Date: 2011-01-07 Impact factor: 3.396

10. Identification of chondroitin polymerizing factor (CHPF) as tumor promotor in cholangiocarcinoma through regulating cell proliferation, cell apoptosis and cell migration.

Authors: Xiaohui Duan; Jianhui Yang; Bo Jiang; Wenbin Duan; Rongguang Wei; Hui Zhang; Xianhai Mao
Journal: Cell Cycle Date: 2021-03-02 Impact factor: 4.534

The biological role of chondroitin sulfate in cancer and chondroitin-based anticancer agents.

1. Humanized chondroitinase ABC sensitizes glioblastoma cells to temozolomide.

2. Chondroitin sulfate as a molecular portal that preferentially mediates the apoptotic killing of tumor cells by penetratin-directed mitochondria-disrupting peptides.

3. MDA-MB-231 breast cancer cell viability, motility and matrix adhesion are regulated by a complex interplay of heparan sulfate, chondroitin-/dermatan sulfate and hyaluronan biosynthesis.

4. Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development.

5. Efficient secretion of biologically active Chondroitinase ABC from mammalian cells in the absence of an N-terminal signal peptide.

6. Prognostic impact of chondroitin-4-sulfotransferase CHST11 in ovarian cancer.

7. Increased expression of chondroitin sulphate proteoglycans in rat hepatocellular carcinoma tissues.

8. Chondroitin Sulfate in Solution: Effects of Mono- and Divalent Salts.

9. Changes in composition and sulfation patterns of glycoaminoglycans in renal cell carcinoma.

10. Identification of chondroitin polymerizing factor (CHPF) as tumor promotor in cholangiocarcinoma through regulating cell proliferation, cell apoptosis and cell migration.