OBJECTIVE: To analyze the prevalence of Helicobacter pylori (H. pylori) infection in children with celiac disease (CD) and to examine the role of H. pylori infection in clinical, laboratory and histopathological presentations of CD. MATERIAL AND METHODS: Data on 96 children with CD and 235 children who underwent endoscopy were compared for the prevalence and gastric histology pattern of H. pylori. Clinical presentation, laboratory and histological findings of CD children with and without H. pylori infection were compared. RESULTS: Twenty-one subjects (21.8%) in the CD group and 56 subjects (23.8%) in the control group had H. pylori gastritis. Gastric metaplasia is higher in CD patients with H. pylori gastritis (19%) than in patients without H. pylori gastritis (1.3%) and in the control group (3.5%) (p<0.05 for all groups). Abdominal distension is more common at initial admission in CD patients with H. pylori gastritis (57.1% versus 14.6%, p<0.05). No significant difference was found between H. pylori (+) and (-) CD patients in terms of prevalence of anemia, iron deficiency and iron-deficiency anemia. Only mild duodenal histological findings were more common in H. pylori patients (57.1% versus 26.7%, p<0.05). CONCLUSIONS: CD may be associated with H. pylori gastritis, but it does not affect the clinical presentation of the disease, except for abdominal distension; CD is associated with mild duodenal lesions. A gluten-free diet improves the symptoms in all patients independently of the presence of H. pylori gastritis. Gastric metaplasia increases in the presence of H. pylori gastritis. Further prospective studies are needed to examine the clinical and histopathological outcomes of gastric metaplasia associated with H. pylori gastritis in CD patients.
OBJECTIVE: To analyze the prevalence of Helicobacter pylori (H. pylori) infection in children with celiac disease (CD) and to examine the role of H. pyloriinfection in clinical, laboratory and histopathological presentations of CD. MATERIAL AND METHODS: Data on 96 children with CD and 235 children who underwent endoscopy were compared for the prevalence and gastric histology pattern of H. pylori. Clinical presentation, laboratory and histological findings of CDchildren with and without H. pyloriinfection were compared. RESULTS: Twenty-one subjects (21.8%) in the CD group and 56 subjects (23.8%) in the control group had H. pylorigastritis. Gastric metaplasia is higher in CDpatients with H. pylorigastritis (19%) than in patients without H. pylorigastritis (1.3%) and in the control group (3.5%) (p<0.05 for all groups). Abdominal distension is more common at initial admission in CDpatients with H. pylorigastritis (57.1% versus 14.6%, p<0.05). No significant difference was found between H. pylori (+) and (-) CDpatients in terms of prevalence of anemia, iron deficiency and iron-deficiency anemia. Only mild duodenal histological findings were more common in H. pyloripatients (57.1% versus 26.7%, p<0.05). CONCLUSIONS:CD may be associated with H. pylorigastritis, but it does not affect the clinical presentation of the disease, except for abdominal distension; CD is associated with mild duodenal lesions. A gluten-free diet improves the symptoms in all patients independently of the presence of H. pylorigastritis. Gastric metaplasia increases in the presence of H. pylorigastritis. Further prospective studies are needed to examine the clinical and histopathological outcomes of gastric metaplasia associated with H. pylorigastritis in CDpatients.
Authors: Benjamin Lebwohl; Martin J Blaser; Jonas F Ludvigsson; Peter H R Green; Andrew Rundle; Amnon Sonnenberg; Robert M Genta Journal: Am J Epidemiol Date: 2013-10-11 Impact factor: 4.897
Authors: Mohammad Rostami-Nejad; Mohammad Javad Ehsani-Ardakani; Hamid Assadzadeh; Bijan Shahbazkhani; Enzo Ierardi; Giuseppe Losurdo; Homayon Zojaji; Amirhoshang Mohammad Alizadeh; Nosratollah Naderi; Amir Sadeghi; Mohammad Reza Zali Journal: Middle East J Dig Dis Date: 2016-04