CONCLUSION: The results suggest that vitamin A can prevent scar formation in the vocal fold after surgery. OBJECTIVES: This study aimed to evaluate the effects of topically applied vitamin A on healing after vocal fold trauma. MATERIALS AND METHODS: Vocal folds of 20 adult rabbits were traumatized unilaterally. Ten of them were treated with topical application of vitamin A and the others served as controls. All animals were sacrificed after 10 days. Vocal folds were resected for analysis by light microscopy. RESULTS: The untreated vocal folds showed extensive deposition of collagen and fibroblast on light microscopy and vocal folds treated with vitamin A showed less deposition. There was a significant difference between the two groups according to the percentage of collagen and fibroblasts in the lamina propria (p<0.01).
CONCLUSION: The results suggest that vitamin A can prevent scar formation in the vocal fold after surgery. OBJECTIVES: This study aimed to evaluate the effects of topically applied vitamin A on healing after vocal fold trauma. MATERIALS AND METHODS: Vocal folds of 20 adult rabbits were traumatized unilaterally. Ten of them were treated with topical application of vitamin A and the others served as controls. All animals were sacrificed after 10 days. Vocal folds were resected for analysis by light microscopy. RESULTS: The untreated vocal folds showed extensive deposition of collagen and fibroblast on light microscopy and vocal folds treated with vitamin A showed less deposition. There was a significant difference between the two groups according to the percentage of collagen and fibroblasts in the lamina propria (p<0.01).
Authors: Nathan V Welham; Seong Hee Choi; Seth H Dailey; Charles N Ford; Jack J Jiang; Diane M Bless Journal: Laryngoscope Date: 2011-05-06 Impact factor: 3.325