Literature DB >> 18607080

Complexes of the copper-containing amine oxidase from Arthrobacter globiformis with the inhibitors benzylhydrazine and tranylcypromine.

David B Langley1, Daniel M Trambaiolo, Anthony P Duff, David M Dooley, Hans C Freeman, J Mitchell Guss.   

Abstract

Complexes of Arthrobacter globiformis amine oxidase (AGAO) with the inhibitors benzylhydrazine and tranylcypromine (an antidepressant drug) have been refined at 1.86 and 1.65 A resolution, respectively. Both inhibitors form covalent adducts with the TPQ cofactor. A tyrosine residue, proposed to act as a gate to the AGAO active site, is in its open conformation.

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Year:  2008        PMID： 18607080      PMCID： PMC2443983          DOI： 10.1107/S174430910801556X

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


  41 in total

1.  PRODRG: a tool for high-throughput crystallography of protein-ligand complexes.

Authors:  Alexander W Schüttelkopf; Daan M F van Aalten
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2004-07-21

2.  Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine.

Authors:  Carrie M Wilmot; Colin G Saysell; Aidan Blessington; Danyl A Conn; Christian R Kurtis; Michael J McPherson; Peter F Knowles; Simon E V Phillips
Journal:  FEBS Lett       Date:  2004-10-22       Impact factor: 4.124

3.  Copper amine oxidase from Hansenula polymorpha: the crystal structure determined at 2.4 A resolution reveals the active conformation.

Authors:  R Li; J P Klinman; F S Mathews
Journal:  Structure       Date:  1998-03-15       Impact factor: 5.006

4.  Inhibition of six copper-containing amine oxidases by the antidepressant drug tranylcypromine.

Authors:  Eric M Shepard; Heather Heggem; Gregory A Juda; David M Dooley
Journal:  Biochim Biophys Acta       Date:  2003-04-11

5.  The 1.23 Angstrom structure of Pichia pastoris lysyl oxidase reveals a lysine-lysine cross-link.

Authors:  Anthony P Duff; Aina E Cohen; Paul J Ellis; Kim Hilmer; David B Langley; David M Dooley; Hans C Freeman; J Mitchell Guss
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2006-08-19

6.  The copper-containing amine oxidase from Arthrobacter globiformis: refinement at 1.55 and 2.20 A resolution in two crystal forms.

Authors:  David B Langley; Anthony P Duff; Hans C Freeman; J Mitchell Guss
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2006-10-25

7.  Role of copper ion in bacterial copper amine oxidase: spectroscopic and crystallographic studies of metal-substituted enzymes.

Authors:  Sei'ichiro Kishishita; Toshihide Okajima; Misa Kim; Hiroshi Yamaguchi; Shun Hirota; Shinnichiro Suzuki; Shun'ichi Kuroda; Katsuyuki Tanizawa; Minae Mure
Journal:  J Am Chem Soc       Date:  2003-01-29       Impact factor: 15.419

8.  Chemical rescue of a site-specific mutant of bacterial copper amine oxidase for generation of the topa quinone cofactor.

Authors:  Hideyuki Matsunami; Toshihide Okajima; Shun Hirota; Hiroshi Yamaguchi; Hiroshi Hori; Shun'ichi Kuroda; Katsuyuki Tanizawa
Journal:  Biochemistry       Date:  2004-03-02       Impact factor: 3.162

9.  Active site rearrangement of the 2-hydrazinopyridine adduct in Escherichia coli amine oxidase to an azo copper(II) chelate form: a key role for tyrosine 369 in controlling the mobility of the TPQ-2HP adduct.

Authors:  Minae Mure; Christian R Kurtis; Doreen E Brown; Melanie S Rogers; Winston S Tambyrajah; Colin Saysell; Carrie M Wilmot; Simon E V Phillips; Peter F Knowles; David M Dooley; Michael J McPherson
Journal:  Biochemistry       Date:  2005-02-08       Impact factor: 3.162

10.  Hydrazine and amphetamine binding to amine oxidases: old drugs with new prospects.

Authors:  P Knowles; C Kurtis; J Murray; C Saysell; W Tambyrajah; C Wilmot; M McPherson; S Phillips; D Dooley; D Brown; M Rogers; M Mure
Journal:  J Neural Transm (Vienna)       Date:  2007-04-04       Impact factor: 3.575
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  4 in total

Review 1.  Copper active sites in biology.

Authors:  Edward I Solomon; David E Heppner; Esther M Johnston; Jake W Ginsbach; Jordi Cirera; Munzarin Qayyum; Matthew T Kieber-Emmons; Christian H Kjaergaard; Ryan G Hadt; Li Tian
Journal:  Chem Rev       Date:  2014-03-03       Impact factor: 60.622

2.  A new crystal form of human diamine oxidase.

Authors:  Aaron P McGrath; Kimberly M Hilmer; Charles A Collyer; David M Dooley; J Mitchell Guss
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2010-01-27

3.  Structure and inhibition of human diamine oxidase.

Authors:  Aaron P McGrath; Kimberly M Hilmer; Charles A Collyer; Eric M Shepard; Bradley O Elmore; Doreen E Brown; David M Dooley; J Mitchell Guss
Journal:  Biochemistry       Date:  2009-10-20       Impact factor: 3.162

4.  Comparing hydrazine-derived reactive groups as inhibitors of quinone-dependent amine oxidases.

Authors:  Ashley A Burke; Elizabeth S Severson; Shreya Mool; Maria J Solares Bucaro; Frederick T Greenaway; Charles E Jakobsche
Journal:  J Enzyme Inhib Med Chem       Date:  2017-12       Impact factor: 5.051
  4 in total

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