| Literature DB >> 18606242 |
Alessandra Abel Borges1, Gelse Mazzoni Campos, Marcos Lázaro Moreli, Ricardo Luiz Moro Souza, Fabiano Pinto Saggioro, Glauciane Garcia Figueiredo, Márcia Cristina Livonesi, Luiz Tadeu Moraes Figueiredo.
Abstract
The hantavirus pulmonary syndrome (HPS) is an emerging syndrome in the Americas. The disease results from intense immune activation and changes in vascular permeability. The aim of this study was to determine the profile of serum cytokines in HPS patients looking for correlation with the clinical parameters, severity and outcome of illness. Studying 21 HPS patients, we found that IL-6 may have an important role in the pathogenesis of HPS, being associated with fatal outcome. Our results also support a mixed Th1/Th2 immune response during the course of HPS and that the magnitude of Th1 response effector cytokines is correlated to HPS severity. The decreased levels of TGF-beta observed in HPS patients suggest that immunoregulatory activity could be damaged in these patients.Entities:
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Year: 2008 PMID： 18606242 DOI： 10.1016/j.micinf.2008.06.006
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700