Literature DB >> 18605719

Gold(I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study.

Divya Krishnamurthy1, Mark R Karver, Edoardo Fiorillo, Valeria Orrú, Stephanie M Stanford, Nunzio Bottini, Amy M Barrios.   

Abstract

Gold(I) complexes containing N-heterocyclic carbene ligands were synthesized, characterized, and along with the antiarthritic drug, auranofin, tested as inhibitors of the cysteine-dependent protein tyrosine phosphatases, which are implicated in several disease states. These compounds exhibit potencies in the low micromolar range against the enzymes in vitro. At therapeutically relevant concentrations, all compounds inhibit PTP activity in Jurkat T leukemia cells with some selectivity. In addition, the gold-carbene compounds inhibit phosphatase activity in primary mouse thymocytes.

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Year:  2008        PMID： 18605719     DOI： 10.1021/jm800101w

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  19 in total

1.  Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis.

Authors:  Michael B Harbut; Catherine Vilchèze; Xiaozhou Luo; Mary E Hensler; Hui Guo; Baiyuan Yang; Arnab K Chatterjee; Victor Nizet; William R Jacobs; Peter G Schultz; Feng Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-23       Impact factor: 11.205

2.  Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors.

Authors:  Rhushikesh A Kulkarni; Nadeem A Vellore; Matthew R Bliss; Stephanie M Stanford; Matthew D Falk; Nunzio Bottini; Riccardo Baron; Amy M Barrios
Journal:  Chembiochem       Date:  2013-08-16       Impact factor: 3.164

3.  Covalent inhibition of the lymphoid tyrosine phosphatase.

Authors:  Vanessa F Ahmed; Nunzio Bottini; Amy M Barrios
Journal:  ChemMedChem       Date:  2014-01-08       Impact factor: 3.466

4.  Target-specific control of lymphoid-specific protein tyrosine phosphatase (Lyp) activity.

Authors:  Zandra E Walton; Anthony C Bishop
Journal:  Bioorg Med Chem       Date:  2010-06-12       Impact factor: 3.641

5.  Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.

Authors:  Stephanie M Stanford; Divya Krishnamurthy; Matthew D Falk; Rossella Messina; Bikash Debnath; Sheng Li; Tong Liu; Roza Kazemi; Russell Dahl; Yantao He; Xiao Yu; Andrew C Chan; Zhong-Yin Zhang; Amy M Barrios; Virgil L Woods; Nouri Neamati; Nunzio Bottini
Journal:  J Med Chem       Date:  2011-02-22       Impact factor: 7.446

Review 6.  Covalent inhibition of protein tyrosine phosphatases.

Authors:  Kasi Viswanatharaju Ruddraraju; Zhong-Yin Zhang
Journal:  Mol Biosyst       Date:  2017-06-27

7.  A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models.

Authors:  Navasona Krishnan; Konstantis F Konidaris; Gilles Gasser; Nicholas K Tonks
Journal:  J Biol Chem       Date:  2017-12-07       Impact factor: 5.157

8.  Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase.

Authors:  Mark R Karver; Divya Krishnamurthy; Nunzio Bottini; Amy M Barrios
Journal:  J Inorg Biochem       Date:  2009-12-28       Impact factor: 4.155

9.  Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes.

Authors:  Mark R Karver; Divya Krishnamurthy; Rhushikesh A Kulkarni; Nunzio Bottini; Amy M Barrios
Journal:  J Med Chem       Date:  2009-11-12       Impact factor: 7.446

10.  Thiuram disulfides as pseudo-irreversible inhibitors of lymphoid tyrosine phosphatase.

Authors:  Rhushikesh A Kulkarni; Stephanie M Stanford; Nadeem A Vellore; Divya Krishnamurthy; Matthew R Bliss; Riccardo Baron; Nunzio Bottini; Amy M Barrios
Journal:  ChemMedChem       Date:  2013-07-19       Impact factor: 3.466
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