Literature DB >> 18604796

Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis.

Andrea Nören-Müller1, Wolfram Wilk, Krishna Saxena, Harald Schwalbe, Markus Kaiser, Herbert Waldmann.   

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Year:  2008        PMID： 18604796     DOI： 10.1002/anie.200801566

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  16 in total

1.  Theoretical studies on the interaction of biphenyl inhibitors with Mycobacterium tuberculosis protein tyrosine phosphatase MptpB.

Authors:  Lihua Dong; Junyou Shi; Yongjun Liu
Journal:  J Mol Model       Date:  2012-03-11       Impact factor: 1.810

2.  Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB.

Authors:  Katherine A Rawls; Christoph Grundner; Jonathan A Ellman
Journal:  Org Biomol Chem       Date:  2010-07-19       Impact factor: 3.876

3.  Bioactivity-guided mapping and navigation of chemical space.

Authors:  Steffen Renner; Willem A L van Otterlo; Marta Dominguez Seoane; Sabine Möcklinghoff; Bettina Hofmann; Stefan Wetzel; Ansgar Schuffenhauer; Peter Ertl; Tudor I Oprea; Dieter Steinhilber; Luc Brunsveld; Daniel Rauh; Herbert Waldmann
Journal:  Nat Chem Biol       Date:  2009-06-28       Impact factor: 15.040

4.  Discovery of new antimalarial chemotypes through chemical methodology and library development.

Authors:  Lauren E Brown; Ken Chih-Chien Cheng; Wan-Guo Wei; Pingwei Yuan; Peng Dai; Richard Trilles; Feng Ni; Jing Yuan; Ryan MacArthur; Rajarshi Guha; Ronald L Johnson; Xin-zhuan Su; Melissa M Dominguez; John K Snyder; Aaron B Beeler; Scott E Schaus; James Inglese; John A Porco
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-15       Impact factor: 11.205

5.  Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics.

Authors:  Jessica D Podoll; Yongxiang Liu; Le Chang; Shane Walls; Wei Wang; Xiang Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-09       Impact factor: 11.205

6.  Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis.

Authors:  Rongjun He; Zhi-Hong Yu; Ruo-Yu Zhang; Li Wu; Andrea M Gunawan; Zhong-Yin Zhang
Journal:  ACS Med Chem Lett       Date:  2015-11-03       Impact factor: 4.345

7.  Nature-inspired stereospecific total synthesis of P-(+)-dispegatrine and four other monomeric sarpagine indole alkaloids.

Authors:  Chitra R Edwankar; Rahul V Edwankar; Jeffrey R Deschamps; James M Cook
Journal:  Angew Chem Int Ed Engl       Date:  2012-10-16       Impact factor: 15.336

8.  A facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B.

Authors:  Li-Fan Zeng; Jie Xu; Yantao He; Rongjun He; Li Wu; Andrea M Gunawan; Zhong-Yin Zhang
Journal:  ChemMedChem       Date:  2013-04-08       Impact factor: 3.466

9.  Stereospecific approach to the synthesis of ring-A oxygenated sarpagine indole alkaloids. Total synthesis of the dimeric indole alkaloid P-(+)-dispegatrine and six other monomeric indole alkaloids.

Authors:  Chitra R Edwankar; Rahul V Edwankar; Ojas A Namjoshi; Xuebin Liao; James M Cook
Journal:  J Org Chem       Date:  2013-06-18       Impact factor: 4.354

10.  Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.

Authors:  Yantao He; Jie Xu; Zhi-Hong Yu; Andrea M Gunawan; Li Wu; Lina Wang; Zhong-Yin Zhang
Journal:  J Med Chem       Date:  2013-01-25       Impact factor: 7.446
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