Literature DB >> 18604586

Casares' map function: no need for a 'corrected' Haldane's map function.

Daniel E Weeks1, Xinyu Tang, Amy M Kwon.   

Abstract

A genetic map function M(d) = RF provides a mapping from the additive genetic distance d to the non-additive recombination fraction RF between a given pair of loci, where the recombination fraction is the proportion of gametes that are recombinant between the two loci. Genetic map functions are needed because in most experiments all we can directly observe are the recombination events. However, since a recombination event is only observed if there are an odd number of crossovers between the two loci, recombination fractions are not additive. One of the most widely used map functions is Haldane's map function, which is derived under the assumptions of no chiasma and no chromatid interference, and has been in widespread use since 1919. However, Casares recently proposed a 'corrected' Haldane's map function - we show here that this 'corrected' map function is not correct due to faulty assumptions and mistakes in its derivation.

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Year:  2008        PMID: 18604586      PMCID: PMC2704907          DOI: 10.1007/s10709-008-9287-1

Source DB:  PubMed          Journal:  Genetica        ISSN: 0016-6707            Impact factor:   1.082


  4 in total

1.  A corrected Haldane's map function to calculate genetic distances from recombination data.

Authors:  Pelayo Casares
Journal:  Genetica       Date:  2006-08-10       Impact factor: 1.082

2.  Multipoint mapping under genetic interference.

Authors:  D E Weeks; G M Lathrop; J Ott
Journal:  Hum Hered       Date:  1993 Mar-Apr       Impact factor: 0.444

3.  Invalidity of the Rao map function for three loci.

Authors:  D E Weeks
Journal:  Hum Hered       Date:  1994 May-Jun       Impact factor: 0.444

4.  Detection of genetic interference: simulation studies and mouse data.

Authors:  D E Weeks; J Ott; G M Lathrop
Journal:  Genetics       Date:  1994-03       Impact factor: 4.562

  4 in total
  1 in total

1.  Amhr2-Cre-Mediated Global Tspo Knockout.

Authors:  Jinjiang Fan; Enrico Campioli; Chantal Sottas; Barry Zirkin; Vassilios Papadopoulos
Journal:  J Endocr Soc       Date:  2020-01-12
  1 in total

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