Literature DB >> 18604454

NDRG2: a Myc-repressed gene involved in cancer and cell stress.

Libo Yao1, Jian Zhang, Xuewu Liu.   

Abstract

As a master switch for cell proliferation and differentiation, Myc exerts its biological functions mainly through transcriptional regulation of its target genes, which are involved in cells?interaction and communication with their external environment. The N-myc downstream-regulated gene (NDRG) family is composed of NDRG1, NDRG2, NDRG3 and NDRG4, which are important in cell proliferation and differentiation. This review summarizes the recent studies on the structure, tissue distribution and functions of NDRG2 that try to show its significance in studying cancer and its therapeutic potential.

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Year:  2008        PMID： 18604454     DOI： 10.1111/j.1745-7270.2008.00434.x

Source DB:  PubMed          Journal:  Acta Biochim Biophys Sin (Shanghai)        ISSN： 1672-9145            Impact factor:   3.848


  49 in total

1.  NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia.

Authors:  Hitomi Yamamoto; Koichi Kokame; Tomohiko Okuda; Yukako Nakajo; Hiroji Yanamoto; Toshiyuki Miyata
Journal:  J Biol Chem       Date:  2011-06-02       Impact factor: 5.157

2.  Ndrg2 expression in neurogenic germinal zones of embryonic and postnatal mouse brain.

Authors:  Lijuan Liu; Ming Shi; Li Wang; Shuangxing Hou; Zhongliang Wu; Gang Zhao; Yanchun Deng
Journal:  J Mol Histol       Date:  2011-12-06       Impact factor: 2.611

3.  Neuroprotective Influence of miR-301a Inhibition in Experimental Cerebral Ischemia/Reperfusion Rat Models Through Targeting NDRG2.

Authors:  Tao Feng; Bang-Hua Han; Gong-Li Yang; Chao-Jie Shi; Zhen-Wen Gao; Ming-Zhi Cao; Xiao-Lei Zhu
Journal:  J Mol Neurosci       Date:  2019-03-20       Impact factor: 3.444

4.  NDRG2 acts as a negative regulator downstream of androgen receptor and inhibits the growth of androgen-dependent and castration-resistant prostate cancer.

Authors:  Chuigong Yu; Guojun Wu; Ruixiao Li; Lei Gao; Fan Yang; Yi Zhao; Jian Zhang; Rui Zhang; Jing Zhang; Libo Yao; Jianlin Yuan; Xia Li
Journal:  Cancer Biol Ther       Date:  2015       Impact factor: 4.742

5.  Inhibition of endothelial cell proliferation and tumor angiogenesis by up-regulating NDRG2 expression in breast cancer cells.

Authors:  Ji Ma; Wenchao Liu; Xiaohong Yan; Qianrong Wang; Qingli Zhao; Yan Xue; Hui Ren; Lin Wu; Yuanxiong Cheng; Sen Li; Lu Miao; Libo Yao; Jian Zhang
Journal:  PLoS One       Date:  2012-02-29       Impact factor: 3.240

6.  Let-7f Regulates the Hypoxic Response in Cerebral Ischemia by Targeting NDRG3.

Authors:  Yaobing Yao; Weiwei Wang; Lijun Jing; Yiwen Wang; Mingzhe Li; Xiaocan Hou; Jing Wang; Tao Peng; Junfang Teng; Yanjie Jia
Journal:  Neurochem Res       Date:  2016-11-04       Impact factor: 3.996

7.  Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice.

Authors:  Graham Dominick; Darlene E Berryman; Edward O List; John J Kopchick; Xinna Li; Richard A Miller; Gonzalo G Garcia
Journal:  Endocrinology       Date:  2014-12-02       Impact factor: 4.736

8.  Evaluation of NDRG2 gene expression in primary papillary thyroid carcinoma and in metastases of this neoplasm to regional lymph nodes.

Authors:  Anna Mordalska; Joanna Latek; Tomasz Ferenc; Lech Pomorski; Elzbieta Gałecka; Arkadiusz Zygmunt; Andrzej Lewiński
Journal:  Thyroid Res       Date:  2010-08-30

9.  NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis.

Authors:  Mengying Wei; Yongzheng Ma; Liangliang Shen; Yuqiao Xu; Lijun Liu; Xin Bu; Zhihao Guo; Hongyan Qin; Zengshan Li; Zhe Wang; Kaichun Wu; Libo Yao; Jipeng Li; Jian Zhang
Journal:  EBioMedicine       Date:  2020-10-21       Impact factor: 8.143

10.  Deficiency of tumor suppressor NDRG2 leads to attention deficit and hyperactive behavior.

Authors:  Yan Li; Anqi Yin; Xin Sun; Ming Zhang; Jianfang Zhang; Ping Wang; Rougang Xie; Wen Li; Ze Fan; Yuanyuan Zhu; Han Wang; Hailong Dong; Shengxi Wu; Lize Xiong
Journal:  J Clin Invest       Date:  2017-10-23       Impact factor: 14.808
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