Literature DB >> 18604449

Wnt signaling: the good and the bad.

Xi Chen1, Jun Yang, Paul M Evans, Chunming Liu.   

Abstract

Since the first Wnt gene was identified in 1982, the functions and mechanisms of Wnt signaling have been extensively studied. Wnt signaling is conserved from invertebrates to vertebrates and regulates early embryonic development as well as the homeostasis of adult tissues. In addition, both embryonic stem cells and adult stem cells are regulated by Wnt signaling. Deregulation of Wnt signaling is associated with many human diseases, particularly cancers. In this review, we will discuss in detail the functions of many components involved in the Wnt signal transduction pathway. Then, we will explore what is known about the role of Wnt signaling in stem cells and cancers.

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Year:  2008        PMID： 18604449      PMCID： PMC2532600          DOI： 10.1111/j.1745-7270.2008.00440.x

Source DB:  PubMed          Journal:  Acta Biochim Biophys Sin (Shanghai)        ISSN： 1672-9145            Impact factor:   3.848


  264 in total

1.  Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.

Authors:  C E Dann; J C Hsieh; A Rattner; D Sharma; J Nathans; D J Leahy
Journal:  Nature       Date:  2001-07-05       Impact factor: 49.962

2.  Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin.

Authors:  B J Merrill; U Gat; R DasGupta; E Fuchs
Journal:  Genes Dev       Date:  2001-07-01       Impact factor: 11.361

3.  The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation.

Authors:  N Barker; A Hurlstone; H Musisi; A Miles; M Bienz; H Clevers
Journal:  EMBO J       Date:  2001-09-03       Impact factor: 11.598

4.  PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.

Authors:  T Q Sun; B Lu; J J Feng; C Reinhard; Y N Jan; W J Fantl; L T Williams
Journal:  Nat Cell Biol       Date:  2001-07       Impact factor: 28.824

5.  beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.

Authors:  J Huelsken; R Vogel; B Erdmann; G Cotsarelis; W Birchmeier
Journal:  Cell       Date:  2001-05-18       Impact factor: 41.582

6.  Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis.

Authors:  S Reddy; T Andl; A Bagasra; M M Lu; D J Epstein; E E Morrisey; S E Millar
Journal:  Mech Dev       Date:  2001-09       Impact factor: 1.882

7.  Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus.

Authors:  X Li; H J Yost; D M Virshup; J M Seeling
Journal:  EMBO J       Date:  2001-08-01       Impact factor: 11.598

8.  Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.

Authors:  J Mao; J Wang; B Liu; W Pan; G H Farr; C Flynn; H Yuan; S Takada; D Kimelman; L Li; D Wu
Journal:  Mol Cell       Date:  2001-04       Impact factor: 17.970

9.  Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan.

Authors:  N S Tolwinski; E Wieschaus
Journal:  Development       Date:  2001-06       Impact factor: 6.868

10.  Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation.

Authors:  S Persad; A A Troussard; T R McPhee; D J Mulholland; S Dedhar
Journal:  J Cell Biol       Date:  2001-06-11       Impact factor: 10.539
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  11 in total

1.  Dynamic expression of a LEF-EGFP Wnt reporter in mouse development and cancer.

Authors:  Nicolas Currier; Kathleen Chea; Mirka Hlavacova; Daniel J Sussman; David C Seldin; Isabel Dominguez
Journal:  Genesis       Date:  2010-03       Impact factor: 2.487

Review 2.  The role of Wnt regulation in heart development, cardiac repair and disease: A tissue engineering perspective.

Authors:  Aric Pahnke; Genna Conant; Locke Davenport Huyer; Yimu Zhao; Nicole Feric; Milica Radisic
Journal:  Biochem Biophys Res Commun       Date:  2015-11-26       Impact factor: 3.575

3.  An ordered EST catalogue and gene expression profiles of cassava (Manihot esculenta) at key growth stages.

Authors:  You-Zhi Li; Ying-Hua Pan; Chang-Bin Sun; Hai-Tao Dong; Xing-Lu Luo; Zhi-Qiang Wang; Ji-Liang Tang; Baoshan Chen
Journal:  Plant Mol Biol       Date:  2010-10-19       Impact factor: 4.076

4.  The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity.

Authors:  Erin A Kimbrel; Andrew L Kung
Journal:  J Biol Chem       Date:  2009-03-17       Impact factor: 5.157

5.  Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity.

Authors:  Tianxin Yu; Xi Chen; Wen Zhang; Juan Li; Ren Xu; Timothy C Wang; Walden Ai; Chunming Liu
Journal:  PLoS One       Date:  2012-02-24       Impact factor: 3.240

6.  Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation.

Authors:  Alejandra B Ochoa-Hernández; Moisés Ramos-Solano; Ivan D Meza-Canales; Beatriz García-Castro; Mónica A Rosales-Reynoso; Judith A Rosales-Aviña; Esperanza Barrera-Chairez; Pablo C Ortíz-Lazareno; Georgina Hernández-Flores; Alejandro Bravo-Cuellar; Luis F Jave-Suarez; Patricio Barros-Núñez; Adriana Aguilar-Lemarroy
Journal:  BMC Cancer       Date:  2012-02-07       Impact factor: 4.430

7.  Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus.

Authors:  Collin M Bantle; C Tenley French; Jason E Cummings; Shankar Sadasivan; Kevin Tran; Richard A Slayden; Richard J Smeyne; Ronald B Tjalkens
Journal:  PLoS One       Date:  2021-01-25       Impact factor: 3.240

8.  Components of the canonical and non-canonical Wnt pathways are not mis-expressed in pituitary tumors.

Authors:  Leandro Machado Colli; Fabiano Saggioro; Luciano Neder Serafini; Renata Costa Camargo; Helio Rubens Machado; Ayrton Custodio Moreira; Sonir R Antonini; Margaret de Castro
Journal:  PLoS One       Date:  2013-04-26       Impact factor: 3.240

9.  Wnt Signaling in Neurogenesis during Aging and Physical Activity.

Authors:  Michael Chen; Huong Do
Journal:  Brain Sci       Date:  2012-12-14

10.  Activating mutations in CTNNB1 in aldosterone producing adenomas.

Authors:  Tobias Åkerström; Rajani Maharjan; Holger Sven Willenberg; Kenko Cupisti; Julian Ip; Ana Moser; Peter Stålberg; Bruce Robinson; K Alexander Iwen; Henning Dralle; Martin K Walz; Hendrik Lehnert; Stan Sidhu; Celso Gomez-Sanchez; Per Hellman; Peyman Björklund
Journal:  Sci Rep       Date:  2016-01-27       Impact factor: 4.379
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