Literature DB >> 18603797

Hypoglycemic effect of 13-membered ring thiocyclitol, a novel alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata).

Hiromi Oe1, Sei Ozaki.   

Abstract

A novel 13-membered ring thiocyclitol, isolated from an aqueous extract of Kothala-himbutu (Salacia reticulata), inhibited alpha-glucosidase in vitro. The inhibitory activity was investigated by maltose- and sucrose-loading on Wistar rats. This study found significant lowering of postprandial glucose levels, and the potency of 13-membered ring thiocyclitol was confirmed in vivo.

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Year:  2008        PMID： 18603797     DOI： 10.1271/bbb.80118

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  7 in total

1.  Quantitative analysis of neosalacinol and neokotalanol, another two potent α-glucosidase inhibitors from Salacia species, by LC-MS with ion pair chromatography.

Authors:  Osamu Muraoka; Toshio Morikawa; Sohachiro Miyake; Junji Akaki; Kiyofumi Ninomiya; Yutana Pongpiriyadacha; Masayuki Yoshikawa
Journal:  J Nat Med       Date:  2010-10-28       Impact factor: 2.343

2.  Modulation of starch digestion for slow glucose release through "toggling" of activities of mucosal α-glucosidases.

Authors:  Byung-Hoo Lee; Razieh Eskandari; Kyra Jones; Kongara Ravinder Reddy; Roberto Quezada-Calvillo; Buford L Nichols; David R Rose; Bruce R Hamaker; B Mario Pinto
Journal:  J Biol Chem       Date:  2012-07-31       Impact factor: 5.157

3.  Salacinol and related analogs: new leads for type 2 diabetes therapeutic candidates from the Thai traditional natural medicine Salacia chinensis.

Authors:  Toshio Morikawa; Junji Akaki; Kiyofumi Ninomiya; Eri Kinouchi; Genzoh Tanabe; Yutana Pongpiriyadacha; Masayuki Yoshikawa; Osamu Muraoka
Journal:  Nutrients       Date:  2015-02-27       Impact factor: 5.717

Review 4.  Salacia reticulata (Kothala himbutu) revisited; a missed opportunity to treat diabetes and obesity?

Authors:  Arjuna B Medagama
Journal:  Nutr J       Date:  2015-02-27       Impact factor: 3.271

Review 5.  Anti-diabetic and Anti-hyperlipidemic Effects and Safety of Salacia reticulata and Related Species.

Authors:  Sidney J Stohs; Sidhartha Ray
Journal:  Phytother Res       Date:  2015-05-31       Impact factor: 5.878

6.  Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice.

Authors:  Tomoko Akase; Tsutomu Shimada; Yukiko Harasawa; Tomohide Akase; Yukinobu Ikeya; Eiichi Nagai; Seiichi Iizuka; Gojiro Nakagami; Shinji Iizaka; Hiromi Sanada; Masaki Aburada
Journal:  Evid Based Complement Alternat Med       Date:  2011-06-23       Impact factor: 2.629

Review 7.  Alpha Glucosidase Inhibitory Activities of Plants with Focus on Common Vegetables.

Authors:  Samuel Tilahun Assefa; Eun-Young Yang; Soo-Young Chae; Mihye Song; Jundae Lee; Myeong-Cheoul Cho; Seonghoe Jang
Journal:  Plants (Basel)       Date:  2019-12-18
  7 in total

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