Literature DB >> 18602966

Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity.

Malgorzata Debiak1, Kai Kehe, Alexander Bürkle.   

Abstract

Sulfur mustard (SM) is a chemical warfare agent leading to severe blistering of skin and mucosal surfaces, and as a long-term effect, to an increased risk for malignancies. At the molecular level, SM acts as a bifunctional alkylating agent, leading to DNA mono-adducts and di-adducts. This review is focussed on the role of poly(ADP-ribosyl)ation in the cell and tissue responses to SM-induced damage and potential role of inhibitors of poly(ADP-ribosyl)ation as therapeutic agents for SM injury.

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Year:  2008        PMID： 18602966     DOI： 10.1016/j.tox.2008.06.002

Source DB:  PubMed          Journal:  Toxicology        ISSN： 0300-483X            Impact factor:   4.221


  11 in total

1.  Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.

Authors:  Vasanthi R Sunil; Kinal Patel-Vayas; Jianliang Shen; Andrew J Gow; Jeffrey D Laskin; Debra L Laskin
Journal:  Toxicol Appl Pharmacol       Date:  2010-11-09       Impact factor: 4.219

2.  Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin.

Authors:  Anil K Jain; Neera Tewari-Singh; Mallikarjuna Gu; Swetha Inturi; Carl W White; Rajesh Agarwal
Journal:  Toxicol Lett       Date:  2011-06-21       Impact factor: 4.372

3.  Inflammatory effects of inhaled sulfur mustard in rat lung.

Authors:  Rama Malaviya; Vasanthi R Sunil; Jessica Cervelli; Dana R Anderson; Wesley W Holmes; Michele L Conti; Ronald E Gordon; Jeffrey D Laskin; Debra L Laskin
Journal:  Toxicol Appl Pharmacol       Date:  2010-07-24       Impact factor: 4.219

4.  Biological and molecular mechanisms of sulfur mustard analogue-induced toxicity in JB6 and HaCaT cells: possible role of ataxia telangiectasia-mutated/ataxia telangiectasia-Rad3-related cell cycle checkpoint pathway.

Authors:  Neera Tewari-Singh; Mallikarjuna Gu; Chapla Agarwal; Carl W White; Rajesh Agarwal
Journal:  Chem Res Toxicol       Date:  2010-06-21       Impact factor: 3.739

5.  Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.

Authors:  Adrienne T Black; Patrick J Hayden; Robert P Casillas; Diane E Heck; Donald R Gerecke; Patrick J Sinko; Debra L Laskin; Jeffrey D Laskin
Journal:  Toxicol Appl Pharmacol       Date:  2010-09-16       Impact factor: 4.219

Review 6.  Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity.

Authors:  Barry Weinberger; Jeffrey D Laskin; Vasanthi R Sunil; Patrick J Sinko; Diane E Heck; Debra L Laskin
Journal:  Pulm Pharmacol Ther       Date:  2010-09-17       Impact factor: 3.410

7.  Time course pathogenesis of sulphur mustard-induced skin lesions in mouse model.

Authors:  Vinay Lomash; Sunil E Jadhav; Rajagopalan Vijayaraghavan; Satish C Pant
Journal:  Int Wound J       Date:  2012-06-04       Impact factor: 3.315

8.  Small-interfering RNA for c-Jun attenuates cell death by preventing JNK-dependent PARP1 cleavage and DNA fragmentation in nitrogen mustard-injured immortalized human bronchial epithelial cells.

Authors:  Feng Ye; Guorong Dan; Yuanpeng Zhao; Wenpei Yu; Jin Cheng; Mingliang Chen; Yan Sai; Zhongmin Zou
Journal:  Toxicol Res (Camb)       Date:  2021-08-31       Impact factor: 2.680

9.  From the Cover: Catalytic Antioxidant Rescue of Inhaled Sulfur Mustard Toxicity.

Authors:  Cameron S McElroy; Elysia Min; Jie Huang; Joan E Loader; Tara B Hendry-Hofer; Rhonda B Garlick; Jackie S Rioux; Livia A Veress; Russell Smith; Chris Osborne; Dana R Anderson; Wesley W Holmes; Danielle C Paradiso; Carl W White; Brian J Day
Journal:  Toxicol Sci       Date:  2016-09-07       Impact factor: 4.849

10.  Effects of poly (ADP-ribose) polymerase-1 (PARP-1) inhibition on sulfur mustard-induced cutaneous injuries in vitro and in vivo.

Authors:  Feng Liu; Ning Jiang; Zhi-Yong Xiao; Jun-Ping Cheng; Yi-Zhou Mei; Pan Zheng; Li Wang; Xiao-Rui Zhang; Xin-Bo Zhou; Wen-Xia Zhou; Yong-Xiang Zhang
Journal:  PeerJ       Date:  2016-04-04       Impact factor: 2.984
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