| Literature DB >> 18602725 |
Odile Launay1, Sophie Grabar, Frédéric Bloch, Corinne Desaint, David Jegou, Christophe Lallemand, Robert Erickson, Pierre Lebon, Michael G Tovey.
Abstract
A randomized double-blind placebo-controlled study was conducted to determine the effect of sublingual administration of IFNalpha on the immune response to influenza vaccination in elderly institutionalized individuals. Sublingual administration of 10 million IU of IFNalpha immediately prior to vaccination, reduced the geometric mean haemagglutination inhibitory (HAI) and IgG2 circulating antibody titers, and the secretory IgA (sIgA) response in saliva, to the New York strain of influenza A virus, 21 days post-vaccination, without detectable drug-related local or systemic toxicity. IFN treatment did not inhibit the immune response to the other components of the vaccine; the New Caledonia strain of influenza A virus, or the Jiangsu strain of influenza B virus. At the dose tested sublingual administration of IFNalpha reduces the immune response to influenza vaccination in elderly institutionalized individuals.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18602725 DOI： 10.1016/j.vaccine.2008.05.035
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641