Literature DB >> 18602448

The LDL receptor-related protein can form homo-dimers in neuronal cells.

Alexandra Makarova1, Kathryn K Bercury, Kenneth W Adams, Daniel Joyner, Meihua Deng, Robert Spoelgen, Mirjam Koker, Dudley K Strickland, Bradley T Hyman.   

Abstract

The ability of the low density lipoprotein receptor-related protein (LRP) to form homo-dimers was studied in mouse neuroblastoma and human neuroglioma cells as well as in primary cortical cultures from adult mouse brain. Homo-dimerization of LRP light chain (LC) was shown by several methods including co-immunoprecipitation, fluorescence lifetime imaging microscopy, and bimolecular fluorescence complementation assay. The requirement of intact NPXY motifs of LRP LC for homo-dimerization was ruled out by co-immunoprecipitation assay.

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Year:  2008        PMID： 18602448      PMCID： PMC2565777          DOI： 10.1016/j.neulet.2008.06.070

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  25 in total

1.  Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.

Authors:  Elena Loukinova; Sripriya Ranganathan; Sergey Kuznetsov; Natalia Gorlatova; Mary M Migliorini; Dmitri Loukinov; Paula G Ulery; Irina Mikhailenko; Daniel A Lawrence; Dudley K Strickland
Journal:  J Biol Chem       Date:  2002-02-19       Impact factor: 5.157

2.  Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain.

Authors:  Petra May; Y Krishna Reddy; Joachim Herz
Journal:  J Biol Chem       Date:  2002-03-20       Impact factor: 5.157

Review 3.  LRP: a multifunctional scavenger and signaling receptor.

Authors:  J Herz; D K Strickland
Journal:  J Clin Invest       Date:  2001-09       Impact factor: 14.808

4.  Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques.

Authors:  Brian J Bacskai; Jesse Skoch; Gregory A Hickey; Racquel Allen; Bradley T Hyman
Journal:  J Biomed Opt       Date:  2003-07       Impact factor: 3.170

5.  Identification and characterization of a dimerization domain in CED-6, an adapter protein involved in engulfment of apoptotic cells.

Authors:  H P Su; E Brugnera; W Van Criekinge; E Smits; M Hengartner; T Bogaert; K S Ravichandran
Journal:  J Biol Chem       Date:  2000-03-31       Impact factor: 5.157

6.  Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP).

Authors:  Hua Poo Su; Kumiko Nakada-Tsukui; Annie-Carole Tosello-Trampont; Yonghe Li; Guojun Bu; Peter M Henson; Kodimangalam S Ravichandran
Journal:  J Biol Chem       Date:  2001-11-29       Impact factor: 5.157

7.  Tyrosine-phosphorylated low density lipoprotein receptor-related protein 1 (Lrp1) associates with the adaptor protein SHC in SRC-transformed cells.

Authors:  H Barnes; B Larsen; M Tyers; P van Der Geer
Journal:  J Biol Chem       Date:  2001-03-20       Impact factor: 5.157

8.  alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons.

Authors:  Zhihua Qiu; Dudley K Strickland; Bradley T Hyman; G William Rebeck
Journal:  J Biol Chem       Date:  2002-02-11       Impact factor: 5.157

9.  The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.

Authors:  Ayae Kinoshita; Tejal Shah; Michelle M Tangredi; Dudley K Strickland; Bradley T Hyman
Journal:  J Biol Chem       Date:  2003-07-29       Impact factor: 5.157

10.  Differential requirements for AP-2 in clathrin-mediated endocytosis.

Authors:  Sean D Conner; Sandra L Schmid
Journal:  J Cell Biol       Date:  2003-09-01       Impact factor: 10.539
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  3 in total

1.  Imaging LDL receptor oligomerization during endocytosis using a co-internalization assay.

Authors:  Peng Zou; Alice Y Ting
Journal:  ACS Chem Biol       Date:  2011-01-14       Impact factor: 5.100

2.  Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE.

Authors:  Patricia A Young; Mary Migliorini; Dudley K Strickland
Journal:  J Biol Chem       Date:  2016-10-29       Impact factor: 5.157

3.  Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis.

Authors:  Alban Gaultier; Xiaohua Wu; Natacha Le Moan; Shinako Takimoto; Gatambwa Mukandala; Katerina Akassoglou; W Marie Campana; Steven L Gonias
Journal:  J Cell Sci       Date:  2009-03-19       Impact factor: 5.285
  3 in total

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