Literature DB >> 18602241

Simultaneous determination of artemether and lumefantrine in fixed dose combination tablets by HPLC with UV detection.

Isabela da Costa César1, Fernando Henrique Andrade Nogueira, Gérson Antônio Pianetti.   

Abstract

This paper describes the development and validation of a HPLC-UV method (210 nm) for the simultaneous quantitation of artemether and lumefantrine in fixed dose combination tablets. The method showed to be linear (r(2)>0.99), precise (R.S.D.<2.0%), accurate (recovery of 101.07% for artemether and 101.58% for lumefantrine), specific and robust. Four batches of artemether-lumefantrine tablets were assayed by the validated method. The artemether contents in the tablets varied from 98.61% to 103.35%, while lumefantrine contents were 97.92-100.48%.

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Year:  2008        PMID： 18602241     DOI： 10.1016/j.jpba.2008.05.022

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  13 in total

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Journal:  Photochem Photobiol Sci       Date:  2019-05-15       Impact factor: 3.982

2.  Artemether-Lumefantrine Concentrations in Tablets and Powders from Ghana Measured by a New High-Performance Liquid Chromatography Method.

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Journal:  Am J Trop Med Hyg       Date:  2016-05-02       Impact factor: 2.345

3.  Stability-indicating HPLC-DAD/UV-ESI/MS impurity profiling of the anti-malarial drug lumefantrine.

Authors:  Mathieu Verbeken; Sultan Suleman; Bram Baert; Elien Vangheluwe; Sylvia Van Dorpe; Christian Burvenich; Luc Duchateau; Frans H Jansen; Bart De Spiegeleer
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4.  Simultaneous quantitation of chloroquine and primaquine by UPLC-DAD and comparison with a HPLC-DAD method.

Authors:  Tiago A Miranda; Pedro H R Silva; Gerson A Pianetti; Isabela C César
Journal:  Malar J       Date:  2015-01-28       Impact factor: 2.979

5.  Simultaneous quantification of artesunate and mefloquine in fixed-dose combination tablets by multivariate calibration with middle infrared spectroscopy and partial least squares regression.

Authors:  Breno Maurício Marson; Raquel de Oliveira Vilhena; Camilla Regina de Souza Madeira; Flávia Lada Degaut Pontes; Mário Sérgio Piantavini; Roberto Pontarolo
Journal:  Malar J       Date:  2016-02-24       Impact factor: 2.979

6.  LC-UV/MS quality analytics of paediatric artemether formulations.

Authors:  Kirsten Vandercruyssen; Matthias D'Hondt; Valentijn Vergote; Herwig Jansen; Christian Burvenich; Bart De Spiegeleer
Journal:  J Pharm Anal       Date:  2013-04-25

7.  Green Analytical Methods of Antimalarial Artemether-Lumefantrine Analysis for Falsification Detection Using a Low-Cost Handled NIR Spectrometer with DD-SIMCA and Drug Quantification by HPLC.

Authors:  Moussa Yabré; Ludivine Ferey; Abdoul Karim Sakira; Camille Bonmatin; Clotilde Fauré; Touridomon Issa Somé; Karen Gaudin
Journal:  Molecules       Date:  2020-07-27       Impact factor: 4.411

8.  A rapid stability-indicating, fused-core HPLC method for simultaneous determination of β-artemether and lumefantrine in anti-malarial fixed dose combination products.

Authors:  Sultan Suleman; Kirsten Vandercruyssen; Evelien Wynendaele; Matthias D'Hondt; Nathalie Bracke; Luc Duchateau; Christian Burvenich; Kathelijne Peremans; Bart De Spiegeleer
Journal:  Malar J       Date:  2013-04-30       Impact factor: 2.979

9.  Determination of artemether and lumefantrine in anti-malarial fixed-dose combination tablets by microemulsion electrokinetic chromatography with short-end injection procedure.

Authors:  N'Cho Christophe Amin; Huguette Fabre; Marie-Dominique Blanchin; Jérôme Montels; Michèle Aké
Journal:  Malar J       Date:  2013-06-13       Impact factor: 2.979

10.  Validated RP-HPLC method for simultaneous determination and quantification of chlorpheniramine maleate, paracetamol and caffeine in tablet formulation.

Authors:  Akwasi Acheampong; Wilfred Owusu Gyasi; Godfred Darko; Joseph Apau; Sylvester Addai-Arhin
Journal:  Springerplus       Date:  2016-05-14
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