Literature DB >> 18602006

Ligand binding by repeat proteins: natural and designed.

Tijana Z Grove1, Aitziber L Cortajarena, Lynne Regan.   

Abstract

Repeat proteins contain tandem arrays of small structural motifs. As a consequence of this architecture, they adopt non-globular, extended structures that present large, highly specific surfaces for ligand binding. Here we discuss recent advances toward understanding the functional role of this unique modular architecture. We showcase specific examples of natural repeat proteins interacting with diverse ligands and also present examples of designed repeat protein-ligand interactions.

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Year:  2008        PMID： 18602006      PMCID： PMC3500881          DOI： 10.1016/j.sbi.2008.05.008

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  37 in total

1.  Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity.

Authors:  Adam J Stein; Gabriele Fuchs; Chunmei Fu; Sandra L Wolin; Karin M Reinisch
Journal:  Cell       Date:  2005-05-20       Impact factor: 41.582

2.  Designed TPR modules as novel anticancer agents.

Authors:  Aitziber L Cortajarena; Fang Yi; Lynne Regan
Journal:  ACS Chem Biol       Date:  2008-03-20       Impact factor: 5.100

3.  Designed armadillo repeat proteins as general peptide-binding scaffolds: consensus design and computational optimization of the hydrophobic core.

Authors:  Fabio Parmeggiani; Riccardo Pellarin; Anders Peter Larsen; Gautham Varadamsetty; Michael T Stumpp; Oliver Zerbe; Amedeo Caflisch; Andreas Plückthun
Journal:  J Mol Biol       Date:  2007-12-14       Impact factor: 5.469

4.  Structural basis of toll-like receptor 3 signaling with double-stranded RNA.

Authors:  Lin Liu; Istvan Botos; Yan Wang; Joshua N Leonard; Joseph Shiloach; David M Segal; David R Davies
Journal:  Science       Date:  2008-04-18       Impact factor: 47.728

Review 5.  Structure and function of KH domains.

Authors:  Roberto Valverde; Laura Edwards; Lynne Regan
Journal:  FEBS J       Date:  2008-04-15       Impact factor: 5.542

6.  A designed ankyrin repeat protein evolved to picomolar affinity to Her2.

Authors:  Christian Zahnd; Emanuel Wyler; Jochen M Schwenk; Daniel Steiner; Michael C Lawrence; Neil M McKern; Frédéric Pecorari; Colin W Ward; Thomas O Joos; Andreas Plückthun
Journal:  J Mol Biol       Date:  2007-03-20       Impact factor: 5.469

7.  Inhibition of caspase-2 by a designed ankyrin repeat protein: specificity, structure, and inhibition mechanism.

Authors:  Andreas Schweizer; Heidi Roschitzki-Voser; Patrick Amstutz; Christophe Briand; Maya Gulotti-Georgieva; Eva Prenosil; H Kaspar Binz; Guido Capitani; Antonio Baici; Andreas Plückthun; Markus G Grütter
Journal:  Structure       Date:  2007-05       Impact factor: 5.006

Review 8.  Structure and function of Toll receptors and their ligands.

Authors:  Nicholas J Gay; Monique Gangloff
Journal:  Annu Rev Biochem       Date:  2007       Impact factor: 23.643

9.  Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors.

Authors:  Gaby Sennhauser; Patrick Amstutz; Christophe Briand; Otso Storchenegger; Markus G Grütter
Journal:  PLoS Biol       Date:  2007-01       Impact factor: 8.029

10.  Structural basis of PP2A inhibition by small t antigen.

Authors:  Uhn Soo Cho; Seamus Morrone; Anna A Sablina; Jason D Arroyo; William C Hahn; Wenqing Xu
Journal:  PLoS Biol       Date:  2007-08       Impact factor: 8.029
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  42 in total

1.  Creating novel proteins by combining design and selection.

Authors:  Tijana Z Grove; Michael Hands; Lynne Regan
Journal:  Protein Eng Des Sel       Date:  2010-03-19       Impact factor: 1.650

2.  Pentatricopeptide repeats of protein-only RNase P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA.

Authors:  Takamasa Teramoto; Kipchumba J Kaitany; Yoshimitsu Kakuta; Makoto Kimura; Carol A Fierke; Traci M Tanaka Hall
Journal:  Nucleic Acids Res       Date:  2020-12-02       Impact factor: 16.971

3.  Structural basis for the modular recognition of single-stranded RNA by PPR proteins.

Authors:  Ping Yin; Quanxiu Li; Chuangye Yan; Ying Liu; Junjie Liu; Feng Yu; Zheng Wang; Jiafu Long; Jianhua He; Hong-Wei Wang; Jiawei Wang; Jian-Kang Zhu; Yigong Shi; Nieng Yan
Journal:  Nature       Date:  2013-10-27       Impact factor: 49.962

4.  Exploring the folding energy landscape of a series of designed consensus tetratricopeptide repeat proteins.

Authors:  Yalda Javadi; Ewan R G Main
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-01       Impact factor: 11.205

5.  Modulating repeat protein stability: the effect of individual helix stability on the collective behavior of the ensemble.

Authors:  Aitziber L Cortajarena; Simon G J Mochrie; Lynne Regan
Journal:  Protein Sci       Date:  2011-05-03       Impact factor: 6.725

6.  All repeats are not equal: a module-based approach to guide repeat protein design.

Authors:  Nicholas Sawyer; Jieming Chen; Lynne Regan
Journal:  J Mol Biol       Date:  2013-02-19       Impact factor: 5.469

7.  The Non-canonical Tetratricopeptide Repeat (TPR) Domain of Fluorescent (FLU) Mediates Complex Formation with Glutamyl-tRNA Reductase.

Authors:  Min Zhang; Feilong Zhang; Ying Fang; Xuemin Chen; Yuhong Chen; Wenxia Zhang; Huai-En Dai; Rongcheng Lin; Lin Liu
Journal:  J Biol Chem       Date:  2015-06-02       Impact factor: 5.157

Review 8.  Tetratricopeptide repeat motifs in the world of bacterial pathogens: role in virulence mechanisms.

Authors:  Lukas Cerveny; Adela Straskova; Vera Dankova; Anetta Hartlova; Martina Ceckova; Frantisek Staud; Jiri Stulik
Journal:  Infect Immun       Date:  2012-12-21       Impact factor: 3.441

9.  Nanostructured functional films from engineered repeat proteins.

Authors:  Tijana Z Grove; Lynne Regan; Aitziber L Cortajarena
Journal:  J R Soc Interface       Date:  2013-04-17       Impact factor: 4.118

10.  A versatile palindromic amphipathic repeat coding sequence horizontally distributed among diverse bacterial and eucaryotic microbes.

Authors:  Kerstin Röske; Mark F Foecking; Shibu Yooseph; John I Glass; Michael J Calcutt; Kim S Wise
Journal:  BMC Genomics       Date:  2010-07-13       Impact factor: 3.969
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