| Literature DB >> 18601949 |
Daniel J Kelley1, Anita Bhattacharyya, Garet P Lahvis, Jerry C P Yin, Jim Malter, Richard J Davidson.
Abstract
Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism.Entities:
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Year: 2008 PMID： 18601949 PMCID： PMC2642647 DOI： 10.1016/j.neubiorev.2008.06.005
Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN： 0149-7634 Impact factor: 8.989